Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 876434..876911 | Replicon | chromosome |
| Accession | NZ_CP084107 | ||
| Organism | Staphylococcus aureus strain CC49/ST49-MSSA | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | LB316_RS04295 | Protein ID | WP_000052076.1 |
| Coordinates | 876434..876622 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | LB316_RS04300 | Protein ID | WP_001059690.1 |
| Coordinates | 876651..876911 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LB316_RS04265 (872422) | 872422..872943 | + | 522 | WP_000824483.1 | hypothetical protein | - |
| LB316_RS04270 (873283) | 873283..873969 | + | 687 | WP_001813074.1 | thermonuclease family protein | - |
| LB316_RS04275 (874326) | 874326..874526 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| LB316_RS04280 (875024) | 875024..875242 | - | 219 | WP_000005880.1 | hypothetical protein | - |
| LB316_RS04285 (875305) | 875305..875589 | - | 285 | WP_001004401.1 | hypothetical protein | - |
| LB316_RS04290 (875677) | 875677..876246 | - | 570 | WP_229375625.1 | lipoprotein N-acylation protein LnsA | - |
| LB316_RS04295 (876434) | 876434..876622 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| LB316_RS04300 (876651) | 876651..876911 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| LB316_RS04305 (877252) | 877252..877455 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| LB316_RS04310 (877452) | 877452..877688 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| LB316_RS04315 (877913) | 877913..878494 | + | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
| LB316_RS04320 (878567) | 878567..879184 | - | 618 | WP_000255553.1 | LysE/ArgO family amino acid transporter | - |
| LB316_RS04325 (879340) | 879340..879834 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| LB316_RS04330 (880233) | 880233..880655 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
| LB316_RS04335 (880803) | 880803..881519 | + | 717 | WP_000150029.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T218120 WP_000052076.1 NZ_CP084107:c876622-876434 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T218120 NZ_CP115551:4833621-4833932 [Salmonella enterica subsp. enterica serovar Bispebjerg]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT218120 WP_001059690.1 NZ_CP084107:c876911-876651 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT218120 NZ_CP115551:4833929-4834375 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTACTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTACTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |