Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 967468..967997 Replicon chromosome
Accession NC_008687
Organism Paracoccus denitrificans PD1222

Toxin (Protein)


Gene name parE Uniprot ID A1B8Q3
Locus tag PDEN_RS19060 Protein ID WP_011750065.1
Coordinates 967710..967997 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0V0Q4K1
Locus tag PDEN_RS19055 Protein ID WP_010396097.1
Coordinates 967468..967713 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PDEN_RS19025 962723..963175 - 453 WP_011750059.1 CoA-binding protein -
PDEN_RS19030 963359..963772 - 414 WP_011750060.1 YHS domain-containing protein -
PDEN_RS19035 963873..964670 - 798 WP_011750061.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
PDEN_RS19045 965152..966009 + 858 WP_011750063.1 hypothetical protein -
PDEN_RS19050 966002..967363 + 1362 WP_011750064.1 plasmid recombination protein -
PDEN_RS19055 967468..967713 + 246 WP_010396097.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
PDEN_RS19060 967710..967997 + 288 WP_011750065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PDEN_RS19065 968056..968589 + 534 WP_041530416.1 hypothetical protein -
PDEN_RS19070 968814..969986 - 1173 WP_011750067.1 ATP-binding protein -
PDEN_RS19075 970314..970523 - 210 WP_011748680.1 hypothetical protein -
PDEN_RS19080 970665..970943 - 279 WP_041530417.1 hypothetical protein -
PDEN_RS19085 970940..971449 - 510 WP_011750069.1 hypothetical protein -
PDEN_RS19090 971446..971628 - 183 WP_028717528.1 hypothetical protein -
PDEN_RS19095 971625..971948 - 324 WP_011750070.1 zinc ribbon domain-containing protein -
PDEN_RS19100 972058..972303 + 246 WP_011750071.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 964899..983622 18723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10768.19 Da        Isoelectric Point: 6.0765

>T21812 WP_011750065.1 NC_008687:967710-967997 [Paracoccus denitrificans PD1222]
VKALAFTVAATVDLEDIWDYTEGEWGLAQARRYAEELRDTCHALASGERRGRKVDVRPGYLKCLSGSHIIFFRDLGDTLE
IVRILHGAQDVERHL

Download         Length: 288 bp

>T21812 NC_008687:967710-967997 [Paracoccus denitrificans PD1222]
GTGAAGGCATTGGCCTTCACCGTCGCGGCAACGGTCGATCTGGAGGATATCTGGGATTATACGGAAGGCGAATGGGGTCT
GGCGCAAGCCCGGCGGTATGCGGAGGAGCTGCGCGACACCTGCCACGCGCTGGCTTCGGGCGAAAGGCGCGGCAGGAAAG
TTGACGTTCGGCCCGGCTATCTGAAGTGCCTGAGCGGGTCGCATATCATCTTTTTCCGGGATCTGGGCGATACGCTGGAA
ATCGTCCGCATCCTGCACGGTGCACAGGACGTCGAGCGGCATTTGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.75 Da        Isoelectric Point: 6.4631

>AT21812 WP_010396097.1 NC_008687:967468-967713 [Paracoccus denitrificans PD1222]
MSRNTSVSLGDHFVSFIDAQVKGGRYGSASDVVRAGLRLLEEHEAKVKALQDALIAGEDSGRAEGFDLDQFIARKMAGRN
A

Download         Length: 246 bp

>AT21812 NC_008687:967468-967713 [Paracoccus denitrificans PD1222]
ATGTCCCGCAACACTTCGGTTTCGCTCGGCGATCACTTCGTCAGCTTCATCGACGCGCAGGTGAAGGGCGGCCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGCTGCGGCTTCTGGAGGAGCACGAGGCCAAGGTAAAGGCCCTCCAGGACGCCC
TGATCGCGGGAGAGGACTCCGGCCGGGCGGAGGGCTTCGACCTCGATCAGTTCATTGCCCGCAAGATGGCCGGTCGCAAT
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1B8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V0Q4K1

References