Detailed information of TA system TA218119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 406735..407267
• Replicon: chromosome
• Accession: NZ_CP084107
• Organism: Staphylococcus aureus strain CC49/ST49-MSSA

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: LB316_RS01980
• Protein ID: WP_229375547.1
• Coordinates: 406944..407267 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: LB316_RS01975
• Protein ID: WP_229375545.1
• Coordinates: 406735..406944 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB316_RS01945 (402133)	402133..403032	-	900	WP_229375535.1	Abi family protein	-
LB316_RS01950 (403034)	403034..404248	-	1215	WP_229375537.1	site-specific integrase	-
LB316_RS01955 (405208)	405208..405840	-	633	WP_229375539.1	helix-turn-helix transcriptional regulator	-
LB316_RS01960 (406021)	406021..406257	+	237	WP_229375541.1	helix-turn-helix transcriptional regulator	-
LB316_RS01965 (406312)	406312..406584	+	273	WP_229375543.1	helix-turn-helix domain-containing protein	-
LB316_RS01970 (406596)	406596..406742	+	147	WP_229374473.1	pathogenicity island protein	-
LB316_RS01975 (406735)	406735..406944	+	210	WP_229375545.1	hypothetical protein	Antitoxin
LB316_RS01980 (406944)	406944..407267	+	324	WP_229375547.1	DUF1474 family protein	Toxin
LB316_RS01985 (407333)	407333..409585	+	2253	WP_229375548.1	phage/plasmid primase, P4 family	-
LB316_RS01990 (409857)	409857..410204	+	348	WP_229375549.1	hypothetical protein	-
LB316_RS01995 (410201)	410201..410464	+	264	WP_229375551.1	hypothetical protein	-
LB316_RS02000 (410931)	410931..411272	+	342	WP_001190614.1	hypothetical protein	-
LB316_RS02005 (411303)	411303..411956	+	654	WP_000214170.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	397039..421835	24796

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12598.20 Da
• Isoelectric Point: 4.8227

>T218119 WP_229375547.1 NZ_CP084107:406944-407267 [Staphylococcus aureus]
MNWEIRNLMCDIEIVKEKLEDVATTHTWFVYERFTKRSLKTKEEVVNYGQAYNEHRIHNEQVTELMLSYLKELDGLMNKF
HEIEKASSDVSLATESDDAKNSIKVAE

Nucleotide

• Length: 324 bp

>T218119 NZ_CP115551:c4832388-4832077 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8272.05 Da
• Isoelectric Point: 4.2706

>AT218119 WP_229375545.1 NZ_CP084107:406735-406944 [Staphylococcus aureus]
MNNEQKEVIKDIYSSLESVVNNESTEYTHKIKDGKKEWTETVNREQHLQAMIEWTLQQIENNFEWEGAE

Nucleotide

• Length: 210 bp

>AT218119 NZ_CP115551:c4832076-4831786 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA