Detailed information of TA system TA218112

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4738168..4739849
• Replicon: chromosome
• Accession: NZ_CP084103
• Organism: Klebsiella pneumoniae strain C11

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486LFH0
• Locus tag: K8M04_RS23100
• Protein ID: WP_023328808.1
• Coordinates: 4738168..4739085 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: K8M04_RS23105
• Protein ID: WP_040168753.1
• Coordinates: 4739091..4739849 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8M04_RS23080 (K8M04_23010)	4733474..4734994	+	1521	WP_142485656.1	sugar ABC transporter ATP-binding protein	-
K8M04_RS23085 (K8M04_23015)	4734991..4735989	+	999	WP_002885172.1	ribose ABC transporter permease	-
K8M04_RS23090 (K8M04_23020)	4736020..4736961	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
K8M04_RS23095 (K8M04_23025)	4737036..4738043	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
K8M04_RS23100 (K8M04_23030)	4738168..4739085	-	918	WP_023328808.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
K8M04_RS23105 (K8M04_23035)	4739091..4739849	-	759	WP_040168753.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
K8M04_RS23110 (K8M04_23040)	4739935..4740663	-	729	WP_002885152.1	response regulator transcription factor	-
K8M04_RS23115 (K8M04_23045)	4740936..4743083	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
K8M04_RS23120 (K8M04_23050)	4743080..4743223	-	144	WP_022631365.1	hypothetical protein	-
K8M04_RS23125 (K8M04_23055)	4743661..4744347	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34660.13 Da
• Isoelectric Point: 5.4707

>T218112 WP_023328808.1 NZ_CP084103:c4739085-4738168 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T218112 NZ_CP115551:2027690-2027793 [Salmonella enterica subsp. enterica serovar Bispebjerg]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28578.95 Da
• Isoelectric Point: 10.0870

>AT218112 WP_040168753.1 NZ_CP084103:c4739849-4739091 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNTQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT218112 NZ_CP115551:c2027795-2027650 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Structures

Toxin

• AlphaFold DB: A0A486LFH0