Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4584307..4584823 Replicon chromosome
Accession NZ_CP084103
Organism Klebsiella pneumoniae strain C11

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag K8M04_RS22310 Protein ID WP_004178374.1
Coordinates 4584307..4584591 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K8M04_RS22315 Protein ID WP_002886901.1
Coordinates 4584581..4584823 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M04_RS22285 (K8M04_22215) 4579723..4579986 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K8M04_RS22290 (K8M04_22220) 4580116..4580289 + 174 WP_032408826.1 hypothetical protein -
K8M04_RS22295 (K8M04_22225) 4580292..4581035 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K8M04_RS22300 (K8M04_22230) 4581392..4583530 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K8M04_RS22305 (K8M04_22235) 4583839..4584303 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K8M04_RS22310 (K8M04_22240) 4584307..4584591 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8M04_RS22315 (K8M04_22245) 4584581..4584823 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K8M04_RS22320 (K8M04_22250) 4584901..4586811 - 1911 WP_009486549.1 PRD domain-containing protein -
K8M04_RS22325 (K8M04_22255) 4586834..4587988 - 1155 WP_023280781.1 lactonase family protein -
K8M04_RS22330 (K8M04_22260) 4588055..4588795 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T218111 WP_004178374.1 NZ_CP084103:c4584591-4584307 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T218111 NZ_CP115551:c1029975-1029448 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT218111 WP_002886901.1 NZ_CP084103:c4584823-4584581 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT218111 NZ_CP115551:c1030262-1029972 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References