Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3869458..3870077 Replicon chromosome
Accession NZ_CP084103
Organism Klebsiella pneumoniae strain C11

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K8M04_RS18925 Protein ID WP_002892050.1
Coordinates 3869859..3870077 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K8M04_RS18920 Protein ID WP_002892066.1
Coordinates 3869458..3869832 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M04_RS18910 (K8M04_18870) 3864610..3865803 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K8M04_RS18915 (K8M04_18875) 3865826..3868972 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K8M04_RS18920 (K8M04_18880) 3869458..3869832 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K8M04_RS18925 (K8M04_18885) 3869859..3870077 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K8M04_RS18930 (K8M04_18890) 3870236..3870802 + 567 WP_002892030.1 maltose O-acetyltransferase -
K8M04_RS18935 (K8M04_18895) 3870774..3870914 - 141 WP_004147370.1 hypothetical protein -
K8M04_RS18940 (K8M04_18900) 3870935..3871405 + 471 WP_002892026.1 YlaC family protein -
K8M04_RS18945 (K8M04_18905) 3871380..3872831 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K8M04_RS18950 (K8M04_18910) 3872932..3873630 + 699 WP_004177238.1 GNAT family protein -
K8M04_RS18955 (K8M04_18915) 3873627..3873767 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K8M04_RS18960 (K8M04_18920) 3873767..3874030 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T218109 WP_002892050.1 NZ_CP084103:3869859-3870077 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T218109 NZ_CP115551:863180-863593 [Salmonella enterica subsp. enterica serovar Bispebjerg]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT218109 WP_002892066.1 NZ_CP084103:3869458-3869832 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT218109 NZ_CP115551:862933-863199 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References