Detailed information of TA system TA021810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 358045..358730
• Replicon: chromosome
• Accession: NC_008687
• Organism: Paracoccus denitrificans PD1222

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A1B6X9
• Locus tag: PDEN_RS15860
• Protein ID: WP_011749459.1
• Coordinates: 358045..358470 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A1B6Y0
• Locus tag: PDEN_RS15865
• Protein ID: WP_011749460.1
• Coordinates: 358467..358730 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PDEN_RS15845	354719..356728	+	2010	WP_011749455.1	conjugal transfer protein TraG	-
PDEN_RS15850	356759..357154	+	396	Protein_352	CopG family transcriptional regulator	-
PDEN_RS15855	357306..357848	-	543	WP_041530330.1	AAA family ATPase	-
PDEN_RS15860	358045..358470	-	426	WP_011749459.1	type II toxin-antitoxin system VapC family toxin	Toxin
PDEN_RS15865	358467..358730	-	264	WP_011749460.1	plasmid stabilization protein	Antitoxin
PDEN_RS15870	359010..360014	+	1005	WP_011749461.1	P-type conjugative transfer ATPase TrbB	-
PDEN_RS15875	360011..360343	+	333	WP_011749462.1	TrbC/VirB2 family protein	-
PDEN_RS15880	360343..360624	+	282	WP_011749463.1	VirB3 family type IV secretion system protein	-
PDEN_RS15885	360637..363066	+	2430	Protein_359	conjugal transfer protein TrbE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	aac(3)-Ih	-	181135..361128	179993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15061.32 Da
• Isoelectric Point: 4.7222

>T21810 WP_011749459.1 NC_008687:c358470-358045 [Paracoccus denitrificans PD1222]
MILLDTNVVSEPMREAPNPGVIGWIDDQAIETLHLSAITVAEVRFGIAVLPDGKRKARLQSRFETEILPLFADRILPFDL
AASEAFAALMAHARDKSAAIGKADGYIAAIAAAHRLTVATRDTAPFLAAGVTVIDPWDEAG

Nucleotide

• Length: 426 bp

>T21810 NC_008687:c358470-358045 [Paracoccus denitrificans PD1222]
ATGATCCTGCTTGACACGAATGTCGTCTCCGAACCGATGCGGGAGGCGCCGAATCCCGGCGTGATCGGCTGGATCGACGA
CCAGGCGATCGAGACGCTGCACCTCTCGGCCATCACCGTGGCGGAGGTCCGTTTCGGGATCGCAGTGCTTCCCGACGGCA
AGCGCAAGGCCCGCCTGCAATCCCGTTTCGAAACCGAGATCCTGCCGCTCTTCGCCGACCGCATCCTGCCCTTCGACCTC
GCGGCCTCGGAAGCCTTCGCGGCGCTGATGGCCCATGCCCGGGACAAGAGCGCGGCCATAGGCAAGGCGGACGGCTACAT
CGCCGCCATTGCCGCCGCCCATCGGCTGACCGTGGCCACGCGCGATACGGCACCGTTCCTGGCCGCCGGCGTCACGGTCA
TCGACCCGTGGGACGAGGCCGGTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9852.22 Da
• Isoelectric Point: 10.6440

>AT21810 WP_011749460.1 NC_008687:c358730-358467 [Paracoccus denitrificans PD1222]
MPAITIRNLSAETHRALKMRAAQHGRSTEAEVRDILEQAARPQHRVRLGSLLAEIGREARMTKEEHALFETAIRRDRAPA
QPIDFGE

Nucleotide

• Length: 264 bp

>AT21810 NC_008687:c358730-358467 [Paracoccus denitrificans PD1222]
ATGCCCGCCATCACCATTCGCAATCTGTCCGCCGAGACGCATCGGGCGCTGAAGATGCGCGCGGCGCAGCATGGGCGCAG
CACCGAGGCCGAGGTGCGCGACATTCTCGAACAGGCAGCACGACCCCAGCACCGTGTGCGGCTGGGATCGCTGCTGGCCG
AGATCGGCCGTGAGGCACGGATGACCAAGGAAGAGCACGCCCTGTTCGAGACCGCGATCCGGCGTGACCGGGCCCCTGCC
CAACCGATCGATTTCGGCGAATGA

Structures

Toxin

• AlphaFold DB: A1B6X9

Antitoxin

• AlphaFold DB: A1B6Y0