Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 806100..806757 Replicon chromosome
Accession NZ_CP084103
Organism Klebsiella pneumoniae strain C11

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K8M04_RS03975 Protein ID WP_002916310.1
Coordinates 806347..806757 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K8M04_RS03970 Protein ID WP_002916312.1
Coordinates 806100..806366 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M04_RS03945 (K8M04_03945) 801256..802689 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
K8M04_RS03950 (K8M04_03950) 802808..803536 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K8M04_RS03955 (K8M04_03955) 803586..803897 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K8M04_RS03960 (K8M04_03960) 804061..804720 + 660 WP_002916317.1 hemolysin III family protein -
K8M04_RS03965 (K8M04_03965) 804871..805854 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K8M04_RS03970 (K8M04_03970) 806100..806366 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K8M04_RS03975 (K8M04_03975) 806347..806757 + 411 WP_002916310.1 protein YgfX Toxin
K8M04_RS03980 (K8M04_03980) 806764..807285 - 522 WP_004144730.1 flavodoxin FldB -
K8M04_RS03985 (K8M04_03985) 807386..808282 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K8M04_RS03990 (K8M04_03990) 808305..809018 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8M04_RS03995 (K8M04_03995) 809024..810757 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T218098 WP_002916310.1 NZ_CP084103:806347-806757 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T218098 NZ_CP115464:155431-155724 [Brevundimonas sp. NIBR10]
ATGAGTTTGGCAGCCAGGCAAGACTTGTCGACGATCTATCGGCATGGCGTGGAAGCCTTTGGTCAACGACAGGCCGACCG
CTACATCGACGGGCTTCTCGAAACCCTCGACCTCATAGCTGATTTTCCCGAGATGGCCCGGGTTCGAGACTCGCTGAACC
CTCCTGCCTGCGTCCATGGACATCGTCGTCACGTCATCGTCTATGATTTGCTGGCGGACGAGATCGTATTGATCGTTCGG
ATTCGTCATGCCCTGGAAGACTGGCAAGGCTTGTCAGGAGACATGGAACAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT218098 WP_002916312.1 NZ_CP084103:806100-806366 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218098 NZ_CP115464:155169-155414 [Brevundimonas sp. NIBR10]
ATGGCCACGATGAACATCTCCCTCCCCGATCAGATGAAGGCCTGGGTCGAGGCCCAGTCGGCCGACGGCCGCTATTCGAA
CTCCAGCGACTATGTCCGCGACCTGATCCGCCGCGAGCAGATCAGGGCGGAGAAGATCGCCAACATGCAGCGACTGGTTG
ATGAAGGCCGTGCGAGCGGCGTGTCCGACCAGTCTCCGCGACAGATCATCGACGAGATTCGCGCCGAACTCCGCCAACGC
GCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References