21809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2076726..2077396 Replicon chromosome
Accession NC_008686
Organism Paracoccus denitrificans PD1222

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P8JDY4
Locus tag PDEN_RS10310 Protein ID WP_011748362.1
Coordinates 2076962..2077396 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A1B3S2
Locus tag PDEN_RS10305 Protein ID WP_011748361.1
Coordinates 2076726..2076965 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PDEN_RS10275 2071912..2073273 - 1362 WP_049792366.1 site-specific DNA-methyltransferase -
PDEN_RS10280 2073402..2073797 - 396 WP_011748356.1 HNH endonuclease -
PDEN_RS10285 2073885..2074262 - 378 WP_011748357.1 hypothetical protein -
PDEN_RS10290 2074255..2074455 - 201 WP_036744895.1 hypothetical protein -
PDEN_RS26135 2074800..2076405 - 1606 Protein_2074 hypothetical protein -
PDEN_RS10300 2076402..2076602 - 201 WP_011748360.1 hypothetical protein -
PDEN_RS10305 2076726..2076965 + 240 WP_011748361.1 Arc family DNA-binding protein Antitoxin
PDEN_RS10310 2076962..2077396 + 435 WP_011748362.1 type II toxin-antitoxin system VapC family toxin Toxin
PDEN_RS10315 2077384..2078100 - 717 WP_011748363.1 sigma-70 family RNA polymerase sigma factor -
PDEN_RS10325 2078525..2080687 - 2163 WP_011748365.1 hypothetical protein -
PDEN_RS10330 2081021..2081476 + 456 WP_011748367.1 DUF2924 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2057841..2082801 24960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(3-42)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15536.75 Da        Isoelectric Point: 4.5849

>T21809 WP_011748362.1 NC_008686:2076962-2077396 [Paracoccus denitrificans PD1222]
MIILDTNVVSETMKPAPEPRVIDWLNRQELTTLHLTTISLAELRFGIACLDAGRRRDDLDARLEQMLAEVFPARILSFDE
AAASAFGVLMATARRQGQAVSFADGAIAAIAAAQGYPVASRDTAPFAAMGVEVVDPWHEAAQGR

Download         Length: 435 bp

>T21809 NC_008686:2076962-2077396 [Paracoccus denitrificans PD1222]
ATGATCATCCTCGACACCAATGTCGTCTCGGAGACGATGAAGCCGGCGCCAGAGCCGCGGGTGATCGACTGGCTCAACCG
GCAAGAGCTGACCACCCTGCACCTGACCACCATCAGCCTGGCCGAGTTGCGGTTCGGCATTGCATGCCTGGACGCTGGGC
GTCGTCGGGACGATCTTGACGCGCGGCTCGAGCAGATGCTGGCCGAGGTATTTCCGGCACGTATCCTGTCGTTCGACGAG
GCCGCTGCCAGTGCCTTCGGAGTATTGATGGCAACGGCGCGCCGGCAGGGACAGGCCGTGAGTTTTGCCGATGGCGCGAT
TGCTGCCATTGCCGCGGCACAGGGCTATCCCGTCGCCAGCCGCGACACCGCGCCCTTCGCCGCCATGGGCGTAGAGGTGG
TGGATCCGTGGCACGAGGCGGCTCAAGGCCGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8685.85 Da        Isoelectric Point: 7.2058

>AT21809 WP_011748361.1 NC_008686:2076726-2076965 [Paracoccus denitrificans PD1222]
MAQIVVRQIPEEVHRALKAQAAAHGRSAEAELREIIARAVLPQSRPRAGDLMRSIWSGAETDDLSVERDRTPAKPAGFE

Download         Length: 240 bp

>AT21809 NC_008686:2076726-2076965 [Paracoccus denitrificans PD1222]
ATGGCCCAGATCGTCGTACGCCAGATCCCGGAAGAGGTGCATCGCGCGCTGAAGGCGCAGGCGGCTGCCCATGGTCGCAG
CGCCGAGGCCGAGTTGCGCGAGATCATTGCCCGCGCGGTGCTGCCGCAGTCGCGCCCGCGCGCGGGTGATCTGATGCGCA
GTATCTGGTCCGGCGCCGAGACGGACGACCTTTCGGTCGAACGCGACCGGACGCCCGCGAAGCCGGCCGGTTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P8JDY4

Antitoxin

Source ID Structure
AlphaFold DB A1B3S2

References