Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4673039..4673871 Replicon chromosome
Accession NZ_CP084096
Organism Escherichia coli O78 strain 3

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag LCF29_RS22400 Protein ID WP_000854753.1
Coordinates 4673497..4673871 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag LCF29_RS22395 Protein ID WP_001278232.1
Coordinates 4673039..4673407 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCF29_RS22360 (4668882) 4668882..4669562 + 681 WP_001593697.1 WYL domain-containing protein -
LCF29_RS22365 (4669710) 4669710..4670387 + 678 WP_001097305.1 hypothetical protein -
LCF29_RS22370 (4670393) 4670393..4670626 + 234 WP_001278287.1 DUF905 family protein -
LCF29_RS22375 (4670725) 4670725..4671543 + 819 WP_001234631.1 DUF932 domain-containing protein -
LCF29_RS22380 (4671625) 4671625..4672104 + 480 WP_000860065.1 antirestriction protein -
LCF29_RS22385 (4672116) 4672116..4672592 + 477 WP_001186710.1 RadC family protein -
LCF29_RS22390 (4672655) 4672655..4672876 + 222 WP_000692303.1 DUF987 domain-containing protein -
LCF29_RS22395 (4673039) 4673039..4673407 + 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LCF29_RS22400 (4673497) 4673497..4673871 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
LCF29_RS22405 (4673868) 4673868..4674356 + 489 WP_000777541.1 DUF5983 family protein -
LCF29_RS22410 (4674368) 4674368..4674565 + 198 WP_000839281.1 DUF957 domain-containing protein -
LCF29_RS22415 (4674662) 4674662..4675231 + 570 WP_001290247.1 DUF4942 domain-containing protein -
LCF29_RS22420 (4675980) 4675980..4677518 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T218083 WP_000854753.1 NZ_CP084096:4673497-4673871 [Escherichia coli O78]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T218083 NZ_CP115450:c5800214-5799813 [Kitasatospora sp. HUAS 3-15]
GTGACCGAGGAATTCCTGATCGACACCAGCGCACTGGTGCGGTTGATGCGCGGCCGGGCTGGATCGGCCTGGGACGAGAC
GGTCAACGCCGGGCTGGTGTTGCTGTGCGAGCCGGTCCGCCAGGAGTACCTACGAGCGGTCGGTGGCCGGGCGGACTACT
TCGAGGCGGCCGGCCTGCTGCGCGAGCTCTTCCCGTATCAGCACCTTCGGGACAACGCCTGGCAGGAGGCCGCCGAACTC
CAGGAGCGGCTGGCACAGTCGGGTCGGCACCAATGCGCGAGCCCGGTGGACCTGCTGGTCGCGGTCACGGCGGCGCAGCA
CAAACTCACCGTGCTGCACCTGGATGCCGACTTCGAGACGATCGCCGAACTCACCGGCCAGGTTGTGCGCCGGATCTGCT
AA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT218083 WP_001278232.1 NZ_CP084096:4673039-4673407 [Escherichia coli O78]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT218083 NZ_CP115450:c5800444-5800211 [Kitasatospora sp. HUAS 3-15]
ATGTCCCGCACTGTGATTGACCTCGATGACGAGGCCCTCGCCGACGCAGCGCGCTTCCTCGGCACCACGACCAAGAAGGA
CACCGTCAACGCCGCCCTCCGGGAGATAGCGGATCGGCGGCGGCGTGCGGCGGCGCTCGCCCGGATGCGGGAGATGGTGG
CCGAGGGCAAGATCGACTTCTCGGTCATCGGCTACCCGGACGAGCCTGAGCGGCCTGCGAGGCCGGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References