Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3060541..3061067 | Replicon | chromosome |
| Accession | NZ_CP084096 | ||
| Organism | Escherichia coli O78 strain 3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LCF29_RS14605 | Protein ID | WP_000323025.1 |
| Coordinates | 3060541..3060828 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LCF29_RS14610 | Protein ID | WP_000534858.1 |
| Coordinates | 3060828..3061067 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCF29_RS14555 (3055565) | 3055565..3055780 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| LCF29_RS14560 (3056000) | 3056000..3056170 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| LCF29_RS14565 (3056534) | 3056534..3056749 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| LCF29_RS14570 (3057050) | 3057050..3057262 | + | 213 | WP_000087757.1 | cold shock-like protein CspF | - |
| LCF29_RS14575 (3057317) | 3057317..3057406 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| LCF29_RS14580 (3057684) | 3057684..3058436 | - | 753 | WP_001047135.1 | antitermination protein | - |
| LCF29_RS14585 (3058450) | 3058450..3059499 | - | 1050 | WP_001265195.1 | DUF968 domain-containing protein | - |
| LCF29_RS14590 (3059501) | 3059501..3059779 | - | 279 | WP_032140164.1 | hypothetical protein | - |
| LCF29_RS14595 (3059846) | 3059846..3060097 | - | 252 | WP_000981000.1 | protein Rem | - |
| LCF29_RS14600 (3060314) | 3060314..3060469 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| LCF29_RS14605 (3060541) | 3060541..3060828 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LCF29_RS14610 (3060828) | 3060828..3061067 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LCF29_RS14615 (3061092) | 3061092..3061397 | + | 306 | WP_001326990.1 | protein YdfV | - |
| LCF29_RS14620 (3061600) | 3061600..3061932 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| LCF29_RS14625 (3062369) | 3062369..3062518 | - | 150 | WP_180302674.1 | protein YdfW | - |
| LCF29_RS14630 (3062639) | 3062639..3063688 | - | 1050 | Protein_2873 | ISNCY family transposase | - |
| LCF29_RS14635 (3063743) | 3063743..3064162 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| LCF29_RS14640 (3064203) | 3064203..3065168 | - | 966 | WP_000054506.1 | hypothetical protein | - |
| LCF29_RS14645 (3065149) | 3065149..3065670 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| LCF29_RS14650 (3065654) | 3065654..3065881 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3042612..3076393 | 33781 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T218069 WP_000323025.1 NZ_CP084096:c3060828-3060541 [Escherichia coli O78]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T218069 NZ_CP115447:c3573978-3573550 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT218069 WP_000534858.1 NZ_CP084096:c3061067-3060828 [Escherichia coli O78]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT218069 NZ_CP115447:c3574259-3574002 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGTACCGGCGGCGCCCGGCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGTACCGGCGGCGCCCGGCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|