Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2594437..2596088 Replicon chromosome
Accession NC_008639
Organism Chlorobium phaeobacteroides DSM 266

Toxin (Protein)


Gene name HipA3 Uniprot ID A1BIM9
Locus tag CPHA266_RS11710 Protein ID WP_011746048.1
Coordinates 2594437..2595744 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag CPHA266_RS11715 Protein ID WP_011746049.1
Coordinates 2595741..2596088 (-) Length 116 a.a.

Genomic Context

CPHA266_RS11695CPHA266_RS11705CPHA266_RS11710CPHA266_RS11715CPHA266_RS11720CPHA266_RS11730CPHA266_RS11735CPHA266_RS11740
Location: 2589966..2591321 (1356 bp)
Type: Others
Protein ID: WP_011746046.1
Location: 2592471..2594162 (1692 bp)
Type: Others
Protein ID: WP_011746047.1
Location: 2594437..2595744 (1308 bp)
Type: Toxin
Protein ID: WP_011746048.1
Location: 2595741..2596088 (348 bp)
Type: Antitoxin
Protein ID: WP_011746049.1
Location: 2596532..2597338 (807 bp)
Type: Others
Protein ID: WP_011746050.1
Location: 2597917..2598345 (429 bp)
Type: Others
Protein ID: WP_011746051.1
Location: 2598500..2599588 (1089 bp)
Type: Others
Protein ID: WP_011746052.1
Location: 2599665..2600864 (1200 bp)
Type: Others
Protein ID: WP_011746053.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPHA266_RS116952589966..2591321-1356WP_011746046.1hypothetical protein-
CPHA266_RS117052592471..2594162-1692WP_011746047.1sulfatase-like hydrolase/transferase-
CPHA266_RS117102594437..2595744-1308WP_011746048.1type II toxin-antitoxin system HipA family toxinToxin
CPHA266_RS117152595741..2596088-348WP_011746049.1helix-turn-helix domain-containing proteinAntitoxin
CPHA266_RS117202596532..2597338-807WP_011746050.1SDR family NAD(P)-dependent oxidoreductase-
CPHA266_RS117302597917..2598345-429WP_011746051.1peptidylprolyl isomerase-
CPHA266_RS117352598500..2599588-1089WP_011746052.1mechanosensitive ion channel-
CPHA266_RS117402599665..2600864-1200WP_011746053.1FAD-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2586597..25960889491


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48259.64 Da        Isoelectric Point: 6.9659

>T21806 WP_011746048.1 NC_008639:c2595744-2594437 [Chlorobium phaeobacteroides DSM 266]
VSTTARVNLWGRTIGAVSLGSDAATATFEYDPAFVQSGIEIAPLTMPLSGQLYSFPSLRPETFHGLPGLLADSLPDRFGN
ALIDAWLARSGRTPGSFNAVERLCYTGSRGMGALEYAPAIRLGVSGSAPVEIERLVELASEVLTHRNDLQVWFHDEGKEL
ALGEILRVGTSAGGARAKAVIAWNPETDEVRSGQVKAGKGFEYWLLKFDGVSGNKDKELEDPKGYGAIEYAYYRMALDAG
ITMTPCRLFEENGRRHFMTRRFDRLEDGGKLHMQSLCGIAHYDFNQAGAYGYEQAMQVIRRLGLPMASVEEQFRRMVFNI
VARNQDDHVKNIAFLMDRSGNWSLAPAFDITWSYQPGGAWTSTHQMTMNGKRSGFLPDYFKACAKSASMKRGRAETIVAE
VQDVVRRWHDYAEESRVTPRQRDKIATTLGLEGFV

Download         Length: 1308 bp

>T21806 NC_008639:c2595744-2594437 [Chlorobium phaeobacteroides DSM 266]
GTGAGTACAACAGCAAGGGTAAACCTGTGGGGGCGCACGATCGGGGCTGTATCGCTCGGTAGCGACGCTGCGACTGCAAC
CTTCGAGTACGATCCGGCCTTCGTTCAGAGCGGCATCGAAATCGCCCCGTTGACCATGCCGCTCTCCGGTCAGCTCTACT
CCTTTCCCTCGCTGCGTCCCGAAACCTTCCATGGGCTTCCGGGACTGTTGGCGGATTCGCTGCCGGATCGGTTCGGCAAT
GCGCTGATCGATGCCTGGCTGGCCCGTTCCGGTCGCACACCCGGTTCCTTCAATGCCGTCGAGAGGCTCTGTTATACGGG
GTCTCGGGGCATGGGCGCCCTTGAATATGCTCCAGCCATACGGTTGGGGGTCTCCGGCTCTGCGCCGGTCGAAATCGAAC
GGTTGGTCGAGTTGGCTTCGGAGGTGTTGACCCATCGCAACGATCTGCAGGTCTGGTTCCACGATGAGGGCAAGGAGCTT
GCGCTCGGGGAGATTCTCCGGGTCGGCACCTCCGCGGGCGGAGCGAGAGCCAAGGCGGTGATTGCCTGGAACCCGGAAAC
CGACGAAGTTCGTTCAGGCCAGGTGAAGGCCGGAAAAGGGTTCGAGTACTGGTTGCTCAAGTTCGACGGGGTGAGTGGCA
ACAAGGACAAGGAGCTGGAAGATCCAAAAGGGTACGGTGCAATCGAGTACGCATACTACCGCATGGCGCTGGATGCGGGA
ATCACCATGACGCCCTGCCGACTGTTCGAGGAAAACGGTCGTCGCCATTTTATGACGAGGCGCTTTGACCGGTTGGAGGA
TGGAGGCAAACTGCACATGCAGTCGCTCTGCGGCATAGCGCATTACGACTTCAATCAGGCGGGAGCATACGGGTATGAAC
AGGCGATGCAGGTCATTCGACGCCTTGGTTTGCCGATGGCTTCCGTCGAGGAACAGTTCCGGCGAATGGTGTTCAATATC
GTGGCCCGCAATCAGGATGACCATGTGAAGAACATTGCCTTTCTGATGGACAGGTCGGGCAACTGGTCGCTTGCGCCAGC
GTTCGATATTACCTGGAGCTATCAACCGGGGGGAGCGTGGACATCGACCCATCAGATGACGATGAACGGCAAACGGAGCG
GATTCCTGCCGGACTATTTCAAGGCATGTGCGAAAAGCGCATCCATGAAACGCGGGCGAGCCGAAACCATCGTCGCTGAA
GTGCAGGACGTTGTTCGCAGATGGCATGATTATGCCGAGGAGTCGCGCGTCACTCCCCGACAACGGGATAAGATTGCAAC
AACGCTGGGACTGGAGGGCTTTGTATAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12690.84 Da        Isoelectric Point: 10.8463

>AT21806 WP_011746049.1 NC_008639:c2596088-2595741 [Chlorobium phaeobacteroides DSM 266]
MKIEGTLTDEAILGELGARLAQRRLELQLSQGALAAQAGVSKRTVERVEAGATTQMSSMIRVMRVLGLLERLEALVPEAG
PRPMELLKLKGKARKRARTKQKPAEEKPWTWGDES

Download         Length: 348 bp

>AT21806 NC_008639:c2596088-2595741 [Chlorobium phaeobacteroides DSM 266]
ATGAAAATTGAAGGCACATTGACGGATGAGGCGATTCTTGGTGAGCTGGGCGCTCGGCTGGCGCAGCGTCGGCTGGAACT
TCAGTTGAGTCAGGGAGCGCTTGCCGCGCAGGCGGGCGTATCGAAGCGGACGGTGGAGCGTGTCGAAGCCGGGGCTACGA
CGCAGATGTCGTCCATGATACGGGTTATGCGGGTATTGGGGCTGCTGGAACGGCTGGAGGCTCTGGTGCCGGAGGCGGGG
CCGAGGCCGATGGAGTTGCTGAAGCTGAAAGGCAAGGCGCGAAAGCGTGCAAGAACCAAACAGAAGCCAGCGGAAGAAAA
GCCCTGGACGTGGGGTGACGAGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA1BIM9

Antitoxin

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Source
ID
Structure
No matching records found

References