Detailed information of TA system TA021806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2594437..2596088
• Replicon: chromosome
• Accession: NC_008639
• Organism: Chlorobium phaeobacteroides DSM 266

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: A1BIM9
• Locus tag: CPHA266_RS11710
• Protein ID: WP_011746048.1
• Coordinates: 2594437..2595744 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: CPHA266_RS11715
• Protein ID: WP_011746049.1
• Coordinates: 2595741..2596088 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPHA266_RS11695	2589966..2591321	-	1356	WP_011746046.1	hypothetical protein	-
CPHA266_RS11705	2592471..2594162	-	1692	WP_011746047.1	sulfatase-like hydrolase/transferase	-
CPHA266_RS11710	2594437..2595744	-	1308	WP_011746048.1	type II toxin-antitoxin system HipA family toxin	Toxin
CPHA266_RS11715	2595741..2596088	-	348	WP_011746049.1	helix-turn-helix domain-containing protein	Antitoxin
CPHA266_RS11720	2596532..2597338	-	807	WP_011746050.1	SDR family NAD(P)-dependent oxidoreductase	-
CPHA266_RS11730	2597917..2598345	-	429	WP_011746051.1	peptidylprolyl isomerase	-
CPHA266_RS11735	2598500..2599588	-	1089	WP_011746052.1	mechanosensitive ion channel	-
CPHA266_RS11740	2599665..2600864	-	1200	WP_011746053.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2586597..2596088	9491

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-116)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-68)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 48259.64 Da
• Isoelectric Point: 6.9659

>T21806 WP_011746048.1 NC_008639:c2595744-2594437 [Chlorobium phaeobacteroides DSM 266]
VSTTARVNLWGRTIGAVSLGSDAATATFEYDPAFVQSGIEIAPLTMPLSGQLYSFPSLRPETFHGLPGLLADSLPDRFGN
ALIDAWLARSGRTPGSFNAVERLCYTGSRGMGALEYAPAIRLGVSGSAPVEIERLVELASEVLTHRNDLQVWFHDEGKEL
ALGEILRVGTSAGGARAKAVIAWNPETDEVRSGQVKAGKGFEYWLLKFDGVSGNKDKELEDPKGYGAIEYAYYRMALDAG
ITMTPCRLFEENGRRHFMTRRFDRLEDGGKLHMQSLCGIAHYDFNQAGAYGYEQAMQVIRRLGLPMASVEEQFRRMVFNI
VARNQDDHVKNIAFLMDRSGNWSLAPAFDITWSYQPGGAWTSTHQMTMNGKRSGFLPDYFKACAKSASMKRGRAETIVAE
VQDVVRRWHDYAEESRVTPRQRDKIATTLGLEGFV

Nucleotide

• Length: 1308 bp

>T21806 NC_008639:c2595744-2594437 [Chlorobium phaeobacteroides DSM 266]
GTGAGTACAACAGCAAGGGTAAACCTGTGGGGGCGCACGATCGGGGCTGTATCGCTCGGTAGCGACGCTGCGACTGCAAC
CTTCGAGTACGATCCGGCCTTCGTTCAGAGCGGCATCGAAATCGCCCCGTTGACCATGCCGCTCTCCGGTCAGCTCTACT
CCTTTCCCTCGCTGCGTCCCGAAACCTTCCATGGGCTTCCGGGACTGTTGGCGGATTCGCTGCCGGATCGGTTCGGCAAT
GCGCTGATCGATGCCTGGCTGGCCCGTTCCGGTCGCACACCCGGTTCCTTCAATGCCGTCGAGAGGCTCTGTTATACGGG
GTCTCGGGGCATGGGCGCCCTTGAATATGCTCCAGCCATACGGTTGGGGGTCTCCGGCTCTGCGCCGGTCGAAATCGAAC
GGTTGGTCGAGTTGGCTTCGGAGGTGTTGACCCATCGCAACGATCTGCAGGTCTGGTTCCACGATGAGGGCAAGGAGCTT
GCGCTCGGGGAGATTCTCCGGGTCGGCACCTCCGCGGGCGGAGCGAGAGCCAAGGCGGTGATTGCCTGGAACCCGGAAAC
CGACGAAGTTCGTTCAGGCCAGGTGAAGGCCGGAAAAGGGTTCGAGTACTGGTTGCTCAAGTTCGACGGGGTGAGTGGCA
ACAAGGACAAGGAGCTGGAAGATCCAAAAGGGTACGGTGCAATCGAGTACGCATACTACCGCATGGCGCTGGATGCGGGA
ATCACCATGACGCCCTGCCGACTGTTCGAGGAAAACGGTCGTCGCCATTTTATGACGAGGCGCTTTGACCGGTTGGAGGA
TGGAGGCAAACTGCACATGCAGTCGCTCTGCGGCATAGCGCATTACGACTTCAATCAGGCGGGAGCATACGGGTATGAAC
AGGCGATGCAGGTCATTCGACGCCTTGGTTTGCCGATGGCTTCCGTCGAGGAACAGTTCCGGCGAATGGTGTTCAATATC
GTGGCCCGCAATCAGGATGACCATGTGAAGAACATTGCCTTTCTGATGGACAGGTCGGGCAACTGGTCGCTTGCGCCAGC
GTTCGATATTACCTGGAGCTATCAACCGGGGGGAGCGTGGACATCGACCCATCAGATGACGATGAACGGCAAACGGAGCG
GATTCCTGCCGGACTATTTCAAGGCATGTGCGAAAAGCGCATCCATGAAACGCGGGCGAGCCGAAACCATCGTCGCTGAA
GTGCAGGACGTTGTTCGCAGATGGCATGATTATGCCGAGGAGTCGCGCGTCACTCCCCGACAACGGGATAAGATTGCAAC
AACGCTGGGACTGGAGGGCTTTGTATAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 12690.84 Da
• Isoelectric Point: 10.8463

>AT21806 WP_011746049.1 NC_008639:c2596088-2595741 [Chlorobium phaeobacteroides DSM 266]
MKIEGTLTDEAILGELGARLAQRRLELQLSQGALAAQAGVSKRTVERVEAGATTQMSSMIRVMRVLGLLERLEALVPEAG
PRPMELLKLKGKARKRARTKQKPAEEKPWTWGDES

Nucleotide

• Length: 348 bp

>AT21806 NC_008639:c2596088-2595741 [Chlorobium phaeobacteroides DSM 266]
ATGAAAATTGAAGGCACATTGACGGATGAGGCGATTCTTGGTGAGCTGGGCGCTCGGCTGGCGCAGCGTCGGCTGGAACT
TCAGTTGAGTCAGGGAGCGCTTGCCGCGCAGGCGGGCGTATCGAAGCGGACGGTGGAGCGTGTCGAAGCCGGGGCTACGA
CGCAGATGTCGTCCATGATACGGGTTATGCGGGTATTGGGGCTGCTGGAACGGCTGGAGGCTCTGGTGCCGGAGGCGGGG
CCGAGGCCGATGGAGTTGCTGAAGCTGAAAGGCAAGGCGCGAAAGCGTGCAAGAACCAAACAGAAGCCAGCGGAAGAAAA
GCCCTGGACGTGGGGTGACGAGTCGTGA

Structures

Toxin

• AlphaFold DB: A1BIM9