Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 338377..339008 Replicon chromosome
Accession NZ_CP084096
Organism Escherichia coli O78 strain 3

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag LCF29_RS01620 Protein ID WP_001259385.1
Coordinates 338377..338652 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag LCF29_RS01625 Protein ID WP_000593555.1
Coordinates 338649..339008 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCF29_RS01605 (333381) 333381..334448 + 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -
LCF29_RS01610 (334445) 334445..337180 + 2736 WP_000149185.1 ribosome-associated ATPase/putative transporter RbbA -
LCF29_RS01615 (337180) 337180..338304 + 1125 WP_001314210.1 ABC transporter permease -
LCF29_RS01620 (338377) 338377..338652 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
LCF29_RS01625 (338649) 338649..339008 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LCF29_RS01630 (339058) 339058..339918 - 861 WP_001131795.1 class II aldolase -
LCF29_RS01635 (339950) 339950..340219 - 270 WP_000933060.1 HPr family phosphocarrier protein -
LCF29_RS01640 (340209) 340209..341717 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
LCF29_RS01645 (341710) 341710..343068 - 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
LCF29_RS01650 (343145) 343145..343426 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
LCF29_RS01655 (343423) 343423..343896 - 474 WP_001161550.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T218053 WP_001259385.1 NZ_CP084096:338377-338652 [Escherichia coli O78]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T218053 NZ_CP115447:2584154-2584579 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT218053 WP_000593555.1 NZ_CP084096:338649-339008 [Escherichia coli O78]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT218053 NZ_CP115447:2583927-2584148 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References