Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4295..4830 Replicon plasmid pX14-3-tetA
Accession NZ_CP084056
Organism Escherichia coli strain X14-3

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag LCR13_RS22265 Protein ID WP_000222771.1
Coordinates 4295..4582 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag LCR13_RS22270 Protein ID WP_001139206.1
Coordinates 4579..4830 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCR13_RS22255 (LCR13_22265) 3610..3815 - 206 Protein_1 hypothetical protein -
LCR13_RS22260 (LCR13_22270) 3814..3927 + 114 Protein_2 alkaline phosphatase -
LCR13_RS22265 (LCR13_22275) 4295..4582 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCR13_RS22270 (LCR13_22280) 4579..4830 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LCR13_RS22275 (LCR13_22285) 5413..5682 + 270 Protein_5 hypothetical protein -
LCR13_RS22280 (LCR13_22290) 5911..7311 + 1401 WP_032185977.1 cytochrome ubiquinol oxidase subunit I -
LCR13_RS22285 (LCR13_22295) 7311..8321 + 1011 WP_000510495.1 cytochrome d ubiquinol oxidase subunit II -
LCR13_RS22290 (LCR13_22300) 8321..8449 + 129 WP_001164804.1 DUF2474 domain-containing protein -
LCR13_RS22295 (LCR13_22305) 8554..8967 - 414 Protein_9 collagenase-like protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR / tet(A) / qnrS1 / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id - 1..108559 108559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T218050 WP_000222771.1 NZ_CP084056:c4582-4295 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T218050 NZ_CP115447:2098614-2099024 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT218050 WP_001139206.1 NZ_CP084056:c4830-4579 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT218050 NZ_CP115447:2098388-2098621 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References