Detailed information of TA system TA021805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 2528392..2528957
• Replicon: chromosome
• Accession: NC_008639
• Organism: Chlorobium phaeobacteroides DSM 266

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A1BIH1
• Locus tag: CPHA266_RS11410
• Protein ID: WP_011745995.1
• Coordinates: 2528613..2528957 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A1BIG1
• Locus tag: CPHA266_RS11405
• Protein ID: WP_011745986.1
• Coordinates: 2528392..2528616 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPHA266_RS11365	2523700..2523924	+	225	WP_011745986.1	DUF433 domain-containing protein	-
CPHA266_RS11370	2524216..2524545	-	330	WP_011745987.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CPHA266_RS11375	2524542..2524820	-	279	WP_011745988.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CPHA266_RS11380	2525166..2526221	-	1056	WP_041467728.1	virulence RhuM family protein	-
CPHA266_RS11385	2526224..2526415	-	192	WP_011745991.1	hypothetical protein	-
CPHA266_RS11390	2526586..2526903	-	318	WP_011745992.1	type II toxin-antitoxin system HicB family antitoxin	-
CPHA266_RS11395	2526906..2527157	-	252	WP_011745993.1	type II toxin-antitoxin system HicA family toxin	-
CPHA266_RS11400	2527511..2527978	+	468	Protein_2216	IS110 family transposase	-
CPHA266_RS11405	2528392..2528616	+	225	WP_011745986.1	DUF433 domain-containing protein	Antitoxin
CPHA266_RS11410	2528613..2528957	+	345	WP_011745995.1	DUF5615 family PIN-like protein	Toxin
CPHA266_RS15720	2529014..2529247	-	234	WP_041467370.1	DDE transposase family protein	-
CPHA266_RS11420	2529421..2530368	-	948	WP_011745996.1	CoA ester lyase	-
CPHA266_RS11425	2530596..2530871	-	276	WP_011745997.1	DUF2442 domain-containing protein	-
CPHA266_RS14815	2530852..2530986	-	135	WP_011745998.1	DUF4160 domain-containing protein	-
CPHA266_RS14820	2531317..2531439	-	123	WP_081428239.1	DUF4160 domain-containing protein	-
CPHA266_RS15725	2531552..2531713	+	162	WP_190271885.1	hypothetical protein	-
CPHA266_RS11435	2532269..2532886	+	618	WP_150081112.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-79)

Antitoxin

• Protein of unknown function DUF433 (8-63)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12889.73 Da
• Isoelectric Point: 5.1236

>T21805 WP_011745995.1 NC_008639:2528613-2528957 [Chlorobium phaeobacteroides DSM 266]
MIIWIDAHLSPSLAAWINRNYRTIQAQSLSSLNLQQSDDQTVFYEARKADAVIMSKDSDFLKLVEQHGIPPQILWVTCGN
TSNARMREVLEKTLDKAAELLRSGEKVVEISDLC

Nucleotide

• Length: 345 bp

>T21805 NC_008639:2528613-2528957 [Chlorobium phaeobacteroides DSM 266]
ATGATCATCTGGATTGATGCGCACCTGTCTCCTTCTCTGGCGGCCTGGATCAACCGCAATTACAGAACGATTCAGGCACA
ATCATTGAGCAGTCTGAATTTGCAGCAATCAGATGACCAAACAGTATTTTACGAGGCACGAAAAGCCGACGCAGTCATCA
TGAGCAAAGATTCGGATTTCCTCAAACTTGTCGAACAGCATGGCATCCCACCTCAGATCCTCTGGGTGACTTGCGGAAAC
ACATCGAATGCAAGAATGCGGGAAGTGCTGGAAAAAACCCTTGATAAAGCTGCCGAACTGTTGCGTTCCGGAGAAAAGGT
AGTCGAAATCAGCGATTTATGTTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8334.70 Da
• Isoelectric Point: 4.7526

>AT21805 WP_011745986.1 NC_008639:2528392-2528616 [Chlorobium phaeobacteroides DSM 266]
MNEWQKRITINPDQCGGRPCIRGLRIRVIDILDLLAAGLNQDEILEELPDLEKEDILAALKYASKKLDHPVIAA

Nucleotide

• Length: 225 bp

>AT21805 NC_008639:2528392-2528616 [Chlorobium phaeobacteroides DSM 266]
ATGAACGAGTGGCAAAAGCGGATTACCATCAACCCTGATCAGTGCGGTGGGCGTCCATGCATCCGTGGACTGCGAATCAG
GGTAATCGACATCCTTGACCTCCTTGCCGCAGGCCTGAATCAGGATGAAATACTCGAGGAATTACCCGATCTTGAAAAAG
AGGATATTCTGGCGGCATTGAAATATGCCAGCAAAAAACTCGACCATCCGGTGATTGCGGCATGA

Structures

Toxin

• AlphaFold DB: A1BIH1

Antitoxin

• AlphaFold DB: A1BIG1