Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 2526586..2527157 | Replicon | chromosome |
| Accession | NC_008639 | ||
| Organism | Chlorobium phaeobacteroides DSM 266 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A1BIG8 |
| Locus tag | CPHA266_RS11395 | Protein ID | WP_011745993.1 |
| Coordinates | 2526906..2527157 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | CPHA266_RS11390 | Protein ID | WP_011745992.1 |
| Coordinates | 2526586..2526903 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPHA266_RS11355 | 2521876..2522838 | + | 963 | WP_011745984.1 | DUF4351 domain-containing protein | - |
| CPHA266_RS11360 | 2523254..2523520 | + | 267 | WP_041467727.1 | antitoxin | - |
| CPHA266_RS11365 | 2523700..2523924 | + | 225 | WP_011745986.1 | DUF433 domain-containing protein | - |
| CPHA266_RS11370 | 2524216..2524545 | - | 330 | WP_011745987.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| CPHA266_RS11375 | 2524542..2524820 | - | 279 | WP_011745988.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CPHA266_RS11380 | 2525166..2526221 | - | 1056 | WP_041467728.1 | virulence RhuM family protein | - |
| CPHA266_RS11385 | 2526224..2526415 | - | 192 | WP_011745991.1 | hypothetical protein | - |
| CPHA266_RS11390 | 2526586..2526903 | - | 318 | WP_011745992.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| CPHA266_RS11395 | 2526906..2527157 | - | 252 | WP_011745993.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| CPHA266_RS11400 | 2527511..2527978 | + | 468 | Protein_2216 | IS110 family transposase | - |
| CPHA266_RS11405 | 2528392..2528616 | + | 225 | WP_011745986.1 | DUF433 domain-containing protein | - |
| CPHA266_RS11410 | 2528613..2528957 | + | 345 | WP_011745995.1 | DUF5615 family PIN-like protein | - |
| CPHA266_RS15720 | 2529014..2529247 | - | 234 | WP_041467370.1 | DDE transposase family protein | - |
| CPHA266_RS11420 | 2529421..2530368 | - | 948 | WP_011745996.1 | CoA ester lyase | - |
| CPHA266_RS11425 | 2530596..2530871 | - | 276 | WP_011745997.1 | DUF2442 domain-containing protein | - |
| CPHA266_RS14815 | 2530852..2530986 | - | 135 | WP_011745998.1 | DUF4160 domain-containing protein | - |
| CPHA266_RS14820 | 2531317..2531439 | - | 123 | WP_081428239.1 | DUF4160 domain-containing protein | - |
| CPHA266_RS15725 | 2531552..2531713 | + | 162 | WP_190271885.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9634.07 Da Isoelectric Point: 10.6109
>T21804 WP_011745993.1 NC_008639:c2527157-2526906 [Chlorobium phaeobacteroides DSM 266]
MQKRYKKILDQIFQNPVRSDVQWADIENLLYALGAELSEGKGSRVRIALNEVRAVFHRPHPQKETDKGALQSMRRFLQEA
GVR
MQKRYKKILDQIFQNPVRSDVQWADIENLLYALGAELSEGKGSRVRIALNEVRAVFHRPHPQKETDKGALQSMRRFLQEA
GVR
Download Length: 252 bp
>T21804 NC_008639:c2527157-2526906 [Chlorobium phaeobacteroides DSM 266]
ATGCAAAAGAGATACAAAAAGATTCTTGACCAGATTTTTCAAAATCCGGTTCGTTCCGACGTTCAATGGGCTGACATCGA
GAATCTGTTGTATGCTCTTGGAGCCGAATTGTCTGAAGGGAAGGGCTCACGGGTTCGCATTGCCCTTAATGAAGTTCGTG
CTGTTTTTCACAGACCCCATCCTCAAAAAGAAACAGACAAGGGGGCCTTACAATCCATGAGACGTTTTTTACAAGAAGCT
GGAGTCCGATAA
ATGCAAAAGAGATACAAAAAGATTCTTGACCAGATTTTTCAAAATCCGGTTCGTTCCGACGTTCAATGGGCTGACATCGA
GAATCTGTTGTATGCTCTTGGAGCCGAATTGTCTGAAGGGAAGGGCTCACGGGTTCGCATTGCCCTTAATGAAGTTCGTG
CTGTTTTTCACAGACCCCATCCTCAAAAAGAAACAGACAAGGGGGCCTTACAATCCATGAGACGTTTTTTACAAGAAGCT
GGAGTCCGATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11862.25 Da Isoelectric Point: 4.7396
>AT21804 WP_011745992.1 NC_008639:c2526903-2526586 [Chlorobium phaeobacteroides DSM 266]
MLTYKGYTGHVAYDDESGIFHGEVLDTKDVITFQGTTVDGIETAFRESVDDYLEFCQERGEEPDKPFSGKLVLRMSPELH
HKVFIKATKSGKSLNRWISDTLESA
MLTYKGYTGHVAYDDESGIFHGEVLDTKDVITFQGTTVDGIETAFRESVDDYLEFCQERGEEPDKPFSGKLVLRMSPELH
HKVFIKATKSGKSLNRWISDTLESA
Download Length: 318 bp
>AT21804 NC_008639:c2526903-2526586 [Chlorobium phaeobacteroides DSM 266]
ATGTTGACCTATAAAGGATATACCGGTCATGTTGCATATGATGACGAATCCGGAATTTTTCACGGTGAAGTACTGGATAC
AAAAGATGTCATCACGTTCCAGGGTACAACCGTTGATGGGATAGAGACGGCATTCAGGGAGTCGGTTGATGACTATCTCG
AGTTCTGTCAGGAAAGGGGAGAGGAGCCTGATAAGCCCTTTTCCGGAAAACTGGTGCTGAGAATGAGCCCGGAACTGCAC
CATAAAGTCTTTATCAAGGCTACAAAATCAGGTAAAAGCCTGAATCGATGGATTTCCGATACTCTTGAATCGGCATGA
ATGTTGACCTATAAAGGATATACCGGTCATGTTGCATATGATGACGAATCCGGAATTTTTCACGGTGAAGTACTGGATAC
AAAAGATGTCATCACGTTCCAGGGTACAACCGTTGATGGGATAGAGACGGCATTCAGGGAGTCGGTTGATGACTATCTCG
AGTTCTGTCAGGAAAGGGGAGAGGAGCCTGATAAGCCCTTTTCCGGAAAACTGGTGCTGAGAATGAGCCCGGAACTGCAC
CATAAAGTCTTTATCAAGGCTACAAAATCAGGTAAAAGCCTGAATCGATGGATTTCCGATACTCTTGAATCGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|