Detailed information of TA system TA021803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1579205..1579749
• Replicon: chromosome
• Accession: NC_008639
• Organism: Chlorobium phaeobacteroides DSM 266

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A1BG92
• Locus tag: CPHA266_RS07155
• Protein ID: WP_011745235.1
• Coordinates: 1579205..1579540 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A1BG93
• Locus tag: CPHA266_RS07160
• Protein ID: WP_011745236.1
• Coordinates: 1579537..1579749 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPHA266_RS07100	1574662..1574904	+	243	WP_011745226.1	ribbon-helix-helix domain-containing protein	-
CPHA266_RS07105	1574889..1575233	+	345	WP_011745227.1	type II toxin-antitoxin system PemK/MazF family toxin	-
CPHA266_RS07110	1575249..1575449	-	201	WP_150081078.1	hypothetical protein	-
CPHA266_RS07115	1575439..1575690	+	252	WP_011745228.1	ribbon-helix-helix domain-containing protein	-
CPHA266_RS07120	1575727..1576095	+	369	WP_081428226.1	putative toxin-antitoxin system toxin component, PIN family	-
CPHA266_RS07125	1576336..1576866	+	531	WP_011743929.1	winged helix-turn-helix domain-containing protein	-
CPHA266_RS15195	1576884..1577159	+	276	Protein_1397	transposase	-
CPHA266_RS14710	1577699..1577860	+	162	WP_011745230.1	DUF4160 domain-containing protein	-
CPHA266_RS07135	1577925..1578137	+	213	WP_150081201.1	DUF4160 domain-containing protein	-
CPHA266_RS07140	1578141..1578383	+	243	WP_011745232.1	DUF2442 domain-containing protein	-
CPHA266_RS07145	1578501..1578770	+	270	WP_041467251.1	hypothetical protein	-
CPHA266_RS07150	1578767..1579066	+	300	WP_011745234.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CPHA266_RS07155	1579205..1579540	-	336	WP_011745235.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CPHA266_RS07160	1579537..1579749	-	213	WP_011745236.1	antitoxin MazE family protein	Antitoxin
CPHA266_RS07165	1580069..1581031	-	963	WP_011745237.1	transposase	-
CPHA266_RS07170	1581423..1583399	-	1977	WP_011745238.1	hypothetical protein	-
CPHA266_RS07175	1583420..1584547	-	1128	WP_081428227.1	metallophosphoesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-102)

Antitoxin

• Antitoxin MazE-like (6-68)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12061.01 Da
• Isoelectric Point: 9.6920

>T21803 WP_011745235.1 NC_008639:c1579540-1579205 [Chlorobium phaeobacteroides DSM 266]
MKRGLVVTIALQGDYGKPRPALIVQSDYFSGHPSVTVLPITSELRQTPLFRIDVEPESGNGLRKRSQIMVDKIQTVPAEK
IGKAIGILDEATMMEVNRALALWSGFAGNPG

Nucleotide

• Length: 336 bp

>T21803 NC_008639:c1579540-1579205 [Chlorobium phaeobacteroides DSM 266]
ATGAAACGTGGATTGGTAGTAACGATCGCCTTGCAGGGGGATTACGGCAAACCTCGGCCTGCTTTGATTGTACAATCCGA
TTATTTTTCAGGACATCCGTCGGTAACCGTTTTACCGATTACCAGTGAGTTGCGTCAGACGCCGTTATTCAGAATTGATG
TCGAGCCTGAATCCGGTAATGGATTGCGTAAGCGTTCCCAGATCATGGTCGATAAAATACAGACCGTTCCGGCAGAAAAA
ATCGGCAAAGCCATCGGTATTCTTGACGAAGCAACCATGATGGAAGTCAACAGGGCGCTTGCGCTTTGGTCAGGATTTGC
CGGTAATCCAGGGTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8410.63 Da
• Isoelectric Point: 9.9351

>AT21803 WP_011745236.1 NC_008639:c1579749-1579537 [Chlorobium phaeobacteroides DSM 266]
MKVVTERVKRYRDKLRERGLRPVQIWVADTRRPGFELECRRQSALLKSDAHEKEVLEFLERAADREGWEA

Nucleotide

• Length: 213 bp

>AT21803 NC_008639:c1579749-1579537 [Chlorobium phaeobacteroides DSM 266]
ATGAAGGTTGTTACTGAAAGAGTAAAGCGGTACAGAGACAAGCTTCGGGAGCGAGGGTTGAGACCTGTACAGATATGGGT
GGCAGATACGCGACGCCCGGGATTCGAACTGGAATGTCGCCGTCAATCGGCGTTGCTCAAGTCGGATGCTCATGAAAAGG
AGGTGCTTGAATTCCTTGAGCGGGCAGCAGACCGGGAAGGTTGGGAAGCATGA

Structures

Toxin

• AlphaFold DB: A1BG92

Antitoxin

• AlphaFold DB: A1BG93