Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4814064..4814580 Replicon chromosome
Accession NZ_CP084044
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC12_S471M

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KWJ12_RS23530 Protein ID WP_040216106.1
Coordinates 4814064..4814348 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KWJ12_RS23535 Protein ID WP_064162488.1
Coordinates 4814338..4814580 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWJ12_RS23505 (4809481) 4809481..4809744 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KWJ12_RS23510 (4809874) 4809874..4810047 + 174 WP_032425422.1 hypothetical protein -
KWJ12_RS23515 (4810050) 4810050..4810793 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWJ12_RS23520 (4811150) 4811150..4813288 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWJ12_RS23525 (4813596) 4813596..4814060 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWJ12_RS23530 (4814064) 4814064..4814348 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWJ12_RS23535 (4814338) 4814338..4814580 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWJ12_RS23540 (4814658) 4814658..4816568 - 1911 WP_023325426.1 PRD domain-containing protein -
KWJ12_RS23545 (4816591) 4816591..4817745 - 1155 WP_064162489.1 lactonase family protein -
KWJ12_RS23550 (4817812) 4817812..4818552 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T218023 WP_040216106.1 NZ_CP084044:c4814348-4814064 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T218023 NZ_CP115447:73374-73775 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT218023 WP_064162488.1 NZ_CP084044:c4814580-4814338 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT218023 NZ_CP115447:73142-73381 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References