Detailed information of TA system TA021801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 106689..107317
• Replicon: chromosome
• Accession: NC_008639
• Organism: Chlorobium phaeobacteroides DSM 266

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A1BCN4
• Locus tag: CPHA266_RS00490
• Protein ID: WP_011744001.1
• Coordinates: 106689..107087 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CPHA266_RS00495
• Protein ID: WP_041467130.1
• Coordinates: 107084..107317 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPHA266_RS00465	102059..102997	-	939	WP_011743996.1	hypothetical protein	-
CPHA266_RS00470	103347..104657	+	1311	WP_011743997.1	MFS transporter	-
CPHA266_RS00475	104732..105310	-	579	WP_011743998.1	hypothetical protein	-
CPHA266_RS00480	105373..105780	-	408	WP_011743999.1	hypothetical protein	-
CPHA266_RS00485	106232..106678	+	447	WP_190271928.1	peptide-methionine (R)-S-oxide reductase MsrB	-
CPHA266_RS00490	106689..107087	-	399	WP_011744001.1	type II toxin-antitoxin system VapC family toxin	Toxin
CPHA266_RS00495	107084..107317	-	234	WP_041467130.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CPHA266_RS00500	107423..109033	-	1611	WP_190271899.1	DHA2 family efflux MFS transporter permease subunit	-
CPHA266_RS00505	109147..110133	-	987	WP_011744004.1	HlyD family secretion protein	-
CPHA266_RS00510	110135..110608	-	474	WP_011744005.1	universal stress protein	-
CPHA266_RS00515	110611..111936	-	1326	WP_011744006.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (7-25)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15093.51 Da
• Isoelectric Point: 8.0080

>T21801 WP_011744001.1 NC_008639:c107087-106689 [Chlorobium phaeobacteroides DSM 266]
VRYLLDTNICIYIINSRPADVLKRFRQEQIGTIGISSITAAELTFGVIKSGSEKNRRALEMFFTPLEILPFDGSIIWHYG
RLRYYLEKLGQPIGALDTMIASHALALDTVLVTNNVREFMRVPGLRYENWAE

Nucleotide

• Length: 399 bp

>T21801 NC_008639:c107087-106689 [Chlorobium phaeobacteroides DSM 266]
GTGAGATATCTGCTCGATACCAATATCTGCATCTATATCATCAACTCCCGACCCGCAGATGTACTGAAACGTTTCCGTCA
GGAACAAATCGGCACTATCGGAATATCTTCGATAACGGCGGCTGAGCTGACATTCGGAGTTATAAAGAGCGGCTCCGAAA
AAAATCGGCGCGCATTGGAAATGTTTTTCACCCCGCTGGAAATCCTGCCTTTCGACGGATCGATAATATGGCACTATGGC
CGGTTGCGTTACTACCTTGAAAAACTAGGCCAGCCAATCGGGGCTCTTGACACCATGATCGCATCACATGCTCTCGCACT
GGACACTGTTCTGGTAACGAACAATGTCCGCGAGTTCATGAGGGTTCCCGGACTTCGTTATGAAAACTGGGCTGAATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8819.05 Da
• Isoelectric Point: 4.6892

>AT21801 WP_041467130.1 NC_008639:c107317-107084 [Chlorobium phaeobacteroides DSM 266]
METAKIFQSGRSQAVRLPKEFRFQGKEVLISHFADGVLLLPIDKSWATLEAALEEFEPEFKLEREQPEAEKREAIAS

Nucleotide

• Length: 234 bp

>AT21801 NC_008639:c107317-107084 [Chlorobium phaeobacteroides DSM 266]
ATGGAAACTGCTAAAATTTTTCAATCGGGAAGAAGCCAGGCCGTCAGACTTCCGAAGGAATTCCGGTTCCAGGGGAAAGA
GGTGCTGATCAGCCATTTTGCCGATGGGGTATTGCTTCTGCCAATCGATAAATCATGGGCAACGCTGGAAGCAGCGCTTG
AGGAATTCGAGCCGGAATTCAAACTGGAACGGGAGCAGCCCGAAGCTGAAAAAAGGGAAGCGATTGCATCGTGA

Structures

Toxin

• AlphaFold DB: A1BCN4