Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2377572..2378550 | Replicon | chromosome |
| Accession | NZ_CP084035 | ||
| Organism | Bacillus sp. 41-22 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | J8I6P2 |
| Locus tag | LCF45_RS12155 | Protein ID | WP_002017051.1 |
| Coordinates | 2377572..2378312 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | LCF45_RS12160 | Protein ID | WP_000588712.1 |
| Coordinates | 2378425..2378550 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCF45_RS12125 (LCF45_12100) | 2372674..2373435 | + | 762 | WP_078206840.1 | ABC transporter ATP-binding protein | - |
| LCF45_RS12130 (LCF45_12105) | 2373541..2374251 | + | 711 | WP_002127421.1 | class I SAM-dependent methyltransferase | - |
| LCF45_RS12135 (LCF45_12110) | 2374370..2374783 | + | 414 | WP_002012925.1 | VOC family protein | - |
| LCF45_RS12140 (LCF45_12115) | 2374960..2375592 | - | 633 | WP_002017047.1 | type 1 glutamine amidotransferase family protein | - |
| LCF45_RS12145 (LCF45_12120) | 2375866..2376342 | + | 477 | WP_002017049.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| LCF45_RS12150 (LCF45_12125) | 2376496..2377233 | + | 738 | WP_002032137.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| LCF45_RS12155 (LCF45_12130) | 2377572..2378312 | + | 741 | WP_002017051.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| LCF45_RS12160 (LCF45_12135) | 2378425..2378550 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| LCF45_RS12165 (LCF45_12140) | 2378626..2378802 | + | 177 | WP_003189253.1 | stage II sporulation protein SB | - |
| LCF45_RS12170 (LCF45_12145) | 2378823..2379212 | - | 390 | WP_078206839.1 | YxeA family protein | - |
| LCF45_RS12175 (LCF45_12150) | 2379464..2380933 | + | 1470 | WP_016126945.1 | aminoacyl-histidine dipeptidase | - |
| LCF45_RS12180 (LCF45_12155) | 2381293..2381442 | + | 150 | WP_002069316.1 | hypothetical protein | - |
| LCF45_RS12185 (LCF45_12160) | 2382156..2382815 | + | 660 | WP_003189261.1 | CatB-related O-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28512.20 Da Isoelectric Point: 8.3034
>T218008 WP_002017051.1 NZ_CP084035:2377572-2378312 [Bacillus sp. 41-22]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
>T218008 NZ_CP115182:1404771-1405229 [Diaphorobacter sp. ED-3]
ATGCAACGGCATGGCTGGACGCTGCTCTTCCACGACTGCGTGATTGAGCCGTTGCAGAAACTGCAAGCGGCCGCGAGGCG
CGCGCAGGAGAACGACCCGAAAGGCTTCGAGTCCAATGCCAACGTCAAGCTGTTCCGGGCCTTGAGCCAGTTGATGTTGG
AAGTAGTGCCAGGCGATCCGGCACGCGACGAGTACCGTCAGGGCAATACCTTGGGATCGGCCCACCGCCACTGGCGAAGG
GCCAAAATCGGAAGGCGGTTCCGGCTGTTCTTCCGGTACGACTCGAAGGCGAAGGTCATCGTGTACGCCTGGGTCAACGA
TGAACAGACCCTGCGGTCTTCGGGTAGCAAGTCGGACCCGTATGTCGTCTTCGAGAAGATGCTCGGACGCGGGAACCCGC
CAGACGACTGGCACGCGCTGATACAGGCAAGCAAGCAGGATTGGAGCAAACTGGAATAG
ATGCAACGGCATGGCTGGACGCTGCTCTTCCACGACTGCGTGATTGAGCCGTTGCAGAAACTGCAAGCGGCCGCGAGGCG
CGCGCAGGAGAACGACCCGAAAGGCTTCGAGTCCAATGCCAACGTCAAGCTGTTCCGGGCCTTGAGCCAGTTGATGTTGG
AAGTAGTGCCAGGCGATCCGGCACGCGACGAGTACCGTCAGGGCAATACCTTGGGATCGGCCCACCGCCACTGGCGAAGG
GCCAAAATCGGAAGGCGGTTCCGGCTGTTCTTCCGGTACGACTCGAAGGCGAAGGTCATCGTGTACGCCTGGGTCAACGA
TGAACAGACCCTGCGGTCTTCGGGTAGCAAGTCGGACCCGTATGTCGTCTTCGAGAAGATGCTCGGACGCGGGAACCCGC
CAGACGACTGGCACGCGCTGATACAGGCAAGCAAGCAGGATTGGAGCAAACTGGAATAG
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT218008 WP_000588712.1 NZ_CP084035:2378425-2378550 [Bacillus sp. 41-22]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT218008 NZ_CP115182:1404454-1404771 [Diaphorobacter sp. ED-3]
ATGCCTGCCATCCACGAAGTCGCCACGTTGACCTCCAAGGGCCAGGTCACGCTGCCCAAGCCTATCCGGCAGGCGCTGGG
CGTTGATGCCGGCGGCAAGCTCGCGTTCGATCTGCGGGGCAGCGAAGTCGTCGTCACCCGTGTCGATGCCGAGCACGAGG
ACCCCGCCATCGGCGCGTTCCTGAGCCTGCTGGCCCGCGACATCGAAGCTGGCCGGAACGTCCAAGGCCTGCCCGAGGAT
CTGGCCCGCGCCATGCTGGAGCATGCTGGCCATGGCGTGAACCTGGACGAGGAGATCGACGGGGAAGTGGAACTCTGA
ATGCCTGCCATCCACGAAGTCGCCACGTTGACCTCCAAGGGCCAGGTCACGCTGCCCAAGCCTATCCGGCAGGCGCTGGG
CGTTGATGCCGGCGGCAAGCTCGCGTTCGATCTGCGGGGCAGCGAAGTCGTCGTCACCCGTGTCGATGCCGAGCACGAGG
ACCCCGCCATCGGCGCGTTCCTGAGCCTGCTGGCCCGCGACATCGAAGCTGGCCGGAACGTCCAAGGCCTGCCCGAGGAT
CTGGCCCGCGCCATGCTGGAGCATGCTGGCCATGGCGTGAACCTGGACGAGGAGATCGACGGGGAAGTGGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J8I6P2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366GQT1 |