Detailed information of TA system TA217990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 151158..151792
• Replicon: chromosome
• Accession: NZ_CP084032
• Organism: Pectobacterium colocasium strain LJ1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LCF41_RS00665
• Protein ID: WP_225088251.1
• Coordinates: 151158..151433 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LCF41_RS00670
• Protein ID: WP_180743071.1
• Coordinates: 151430..151792 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCF41_RS00650	148186..149556	-	1371	WP_225086474.1	envelope stress sensor histidine kinase CpxA	-
LCF41_RS00655	149553..150251	-	699	WP_225086475.1	envelope stress response regulator transcription factor CpxR	-
LCF41_RS00660	150405..150929	+	525	WP_225086476.1	cell-envelope stress modulator CpxP	-
LCF41_RS00665	151158..151433	+	276	WP_225088251.1	type II toxin-antitoxin system HicA family toxin	Toxin
LCF41_RS00670	151430..151792	+	363	WP_180743071.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LCF41_RS00675	152167..153354	+	1188	WP_225088252.1	sugar transporter	-
LCF41_RS00680	153511..154413	+	903	WP_225088253.1	CDF family cation-efflux transporter FieF	-
LCF41_RS00685	154619..155581	+	963	WP_225086477.1	6-phosphofructokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10024.61 Da
• Isoelectric Point: 11.1875

>T217990 WP_225088251.1 NZ_CP084032:151158-151433 [Pectobacterium colocasium]
MQGKLASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T217990 NZ_CP115150:4416164-4416382 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13529.36 Da
• Isoelectric Point: 4.4969

>AT217990 WP_180743071.1 NZ_CP084032:151430-151792 [Pectobacterium colocasium]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNAFIVETLNEHMKQV

Nucleotide

• Length: 363 bp

>AT217990 NZ_CP115150:4415762-4416136 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA