Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafQ-relB/YafQ-DinJ
Location 1212259..1212793 Replicon chromosome
Accession NC_008618
Organism Bifidobacterium adolescentis ATCC 15703

Toxin (Protein)


Gene name yafQ Uniprot ID A0A1X2ZBX5
Locus tag BAD_RS05205 Protein ID WP_041777341.1
Coordinates 1212512..1212793 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V8QB77
Locus tag BAD_RS05200 Protein ID WP_041777340.1
Coordinates 1212259..1212519 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAD_RS05185 1208286..1210061 + 1776 WP_011743335.1 glycoside hydrolase family 13 protein -
BAD_RS05190 1210115..1211482 + 1368 WP_011743336.1 ABC transporter substrate-binding protein -
BAD_RS05195 1211601..1212065 + 465 WP_041777339.1 D-aminoacyl-tRNA deacylase -
BAD_RS05200 1212259..1212519 + 261 WP_041777340.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BAD_RS05205 1212512..1212793 + 282 WP_041777341.1 type II toxin-antitoxin system YafQ family toxin Toxin
BAD_RS05210 1212812..1213009 - 198 WP_041777342.1 hypothetical protein -
BAD_RS05215 1213113..1215251 - 2139 WP_011743338.1 DUF2075 domain-containing protein -
BAD_RS05220 1215311..1215634 + 324 WP_039198631.1 nucleotide pyrophosphohydrolase -
BAD_RS05225 1216086..1216970 + 885 WP_085379702.1 Abi family protein -
BAD_RS05230 1217062..1217415 - 354 WP_011743341.1 nucleotidyltransferase domain-containing protein -
BAD_RS05235 1217412..1217732 - 321 WP_011743342.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11090.90 Da        Isoelectric Point: 10.2491

>T21799 WP_041777341.1 NC_008618:1212512-1212793 [Bifidobacterium adolescentis ATCC 15703]
MLKSVFRTTQFKKDFKVLLKKHYSPDKLKQAIDALMAQNKQLLSTKYRDHPLTGNWKGYREIHIEGDWLVIYRVEKQELQ
LVLTRTGSHDDLF

Download         Length: 282 bp

>T21799 NC_008618:1212512-1212793 [Bifidobacterium adolescentis ATCC 15703]
ATGCTTAAATCGGTCTTTCGTACAACACAGTTCAAGAAGGATTTCAAGGTTCTGCTCAAAAAACACTATAGTCCCGATAA
GCTTAAACAAGCCATTGACGCACTCATGGCTCAGAACAAGCAACTACTCAGCACAAAATACCGCGACCATCCGCTGACTG
GAAATTGGAAAGGATATCGCGAAATCCATATCGAGGGTGACTGGCTTGTGATTTATCGCGTGGAAAAGCAGGAACTGCAA
CTCGTGCTCACACGGACCGGGTCGCATGATGATCTGTTCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9656.83 Da        Isoelectric Point: 4.6028

>AT21799 WP_041777340.1 NC_008618:1212259-1212519 [Bifidobacterium adolescentis ATCC 15703]
MSDTATISFRTDPAIKREAKELYADMGMDLSTAINIFLRQSIRENGMPFKITRDNPSSIEARRQAETHDGESFTSTDALM
KDLLDA

Download         Length: 261 bp

>AT21799 NC_008618:1212259-1212519 [Bifidobacterium adolescentis ATCC 15703]
ATGAGCGACACTGCGACGATTAGTTTCCGCACGGACCCAGCGATCAAGCGAGAGGCAAAGGAACTGTATGCCGATATGGG
CATGGATCTGTCAACGGCAATCAACATCTTTCTGCGCCAATCAATCCGCGAAAACGGCATGCCTTTCAAGATCACCAGGG
ACAATCCGTCCAGCATTGAGGCACGCCGCCAAGCGGAAACCCATGACGGAGAATCCTTCACCAGCACGGATGCGTTGATG
AAGGATCTGCTGGATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X2ZBX5

Antitoxin

Source ID Structure
AlphaFold DB A0A1V8QB77

References