Detailed information of TA system TA217988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4641502..4643075
• Replicon: chromosome
• Accession: NZ_CP084031
• Organism: Aeromonas caviae strain K433

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2I8R9Y0
• Locus tag: LCG53_RS21715
• Protein ID: WP_047437768.1
• Coordinates: 4641502..4642821 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LCG53_RS21720
• Protein ID: WP_017410478.1
• Coordinates: 4642821..4643075 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCG53_RS21700 (LCG53_21700)	4637405..4638169	+	765	WP_113069309.1	ATP-binding cassette domain-containing protein	-
LCG53_RS21705 (LCG53_21705)	4638201..4639103	+	903	WP_113070596.1	ABC transporter substrate-binding protein	-
LCG53_RS21710 (LCG53_21710)	4639100..4641082	+	1983	WP_113069311.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
LCG53_RS21715 (LCG53_21715)	4641502..4642821	-	1320	WP_047437768.1	type II toxin-antitoxin system HipA family toxin	Toxin
LCG53_RS21720 (LCG53_21720)	4642821..4643075	-	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
LCG53_RS21725 (LCG53_21725)	4643518..4644722	+	1205	WP_102948393.1	IS3 family transposase	-
LCG53_RS21730 (LCG53_21730)	4645109..4646122	-	1014	WP_000845039.1	class 1 integron integrase IntI1	-
LCG53_RS21735 (LCG53_21735)	4646267..4646764	+	498	WP_001083725.1	trimethoprim-resistant dihydrofolate reductase DfrA12	-
LCG53_RS21740 (LCG53_21740)	4646876..4647166	+	291	WP_001336345.1	DUF1010 domain-containing protein	-
LCG53_RS21745 (LCG53_21745)	4647172..4648010	+	839	Protein_4199	AadA family aminoglycoside 3''-O-nucleotidyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49536.51 Da
• Isoelectric Point: 6.8810

>T217988 WP_047437768.1 NZ_CP084031:c4642821-4641502 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T217988 NZ_CP115150:2726505-2726608 [Enterobacter hormaechei subsp. xiangfangensis]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT217988 WP_017410478.1 NZ_CP084031:c4643075-4642821 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT217988 NZ_CP115150:c2726615-2726412 [Enterobacter hormaechei subsp. xiangfangensis]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTG
GTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Structures

Toxin

• AlphaFold DB: A0A2I8R9Y0