Detailed information of TA system TA021797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2646632..2647139
• Replicon: chromosome
• Accession: NC_008609
• Organism: Pelobacter propionicus DSM 2379

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A1ART2
• Locus tag: PPRO_RS12110
• Protein ID: WP_011736308.1
• Coordinates: 2646632..2646892 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A1ART3
• Locus tag: PPRO_RS12115
• Protein ID: WP_011736309.1
• Coordinates: 2646885..2647139 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PPRO_RS12090	2641717..2642583	-	867	WP_157040006.1	exosortase/archaeosortase family protein	-
PPRO_RS12095	2643118..2643834	+	717	WP_011736305.1	Crp/Fnr family transcriptional regulator	-
PPRO_RS12100	2643892..2645370	-	1479	WP_049759715.1	fibronectin type III domain-containing protein	-
PPRO_RS12105	2645847..2646458	-	612	WP_157040108.1	YdcF family protein	-
PPRO_RS12110	2646632..2646892	-	261	WP_011736308.1	Txe/YoeB family addiction module toxin	Toxin
PPRO_RS12115	2646885..2647139	-	255	WP_011736309.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PPRO_RS12120	2647325..2647741	-	417	WP_011736310.1	type II toxin-antitoxin system HicB family antitoxin	-
PPRO_RS12125	2647898..2649151	-	1254	WP_157040007.1	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-
PPRO_RS12130	2649045..2649722	-	678	WP_041532304.1	PEP-CTERM sorting domain-containing protein	-
PPRO_RS20970	2650028..2651620	-	1593	WP_157040008.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10324.83 Da
• Isoelectric Point: 7.9860

>T21797 WP_011736308.1 NC_008609:c2646892-2646632 [Pelobacter propionicus DSM 2379]
MPDRLVWTFAAWEDYQYWQTQDKKTLKRINLLIRDAMRSPFEGIGKPEALRENLSGFWSRRIDETNRLIYAVDGIDLVVI
ACRYHY

Nucleotide

• Length: 261 bp

>T21797 NC_008609:c2646892-2646632 [Pelobacter propionicus DSM 2379]
ATGCCTGACCGACTGGTCTGGACATTCGCAGCCTGGGAAGACTATCAGTACTGGCAGACCCAGGATAAAAAGACGCTGAA
ACGCATCAACCTGCTGATCCGGGATGCCATGCGCAGTCCGTTTGAAGGAATTGGCAAGCCCGAGGCCTTGAGGGAAAATC
TTTCCGGCTTCTGGTCCCGTCGCATTGATGAGACGAATCGTCTGATATACGCTGTGGATGGCATCGATCTGGTCGTGATT
GCCTGTCGTTACCACTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9446.70 Da
• Isoelectric Point: 6.6410

>AT21797 WP_011736309.1 NC_008609:c2647139-2646885 [Pelobacter propionicus DSM 2379]
MRVVNFSDARNHLKHVIDQTIEDSDYTIISRRDSPGAVLMSLDTFNSLMETVHLLKTPANAAHLAKSIEQYRAGQLVHEK
LTDA

Nucleotide

• Length: 255 bp

>AT21797 NC_008609:c2647139-2646885 [Pelobacter propionicus DSM 2379]
ATGAGGGTTGTGAATTTTTCCGATGCACGCAATCATCTAAAACATGTGATCGACCAGACAATTGAAGATTCGGATTATAC
GATCATCTCAAGGCGGGATTCTCCAGGCGCCGTTCTCATGTCCCTCGACACTTTCAACAGCCTCATGGAGACCGTTCATC
TCCTGAAAACACCTGCCAACGCAGCCCACCTTGCCAAATCAATCGAACAGTACCGAGCGGGACAACTGGTACACGAAAAA
CTGACCGATGCCTGA

Structures

Toxin

• AlphaFold DB: A1ART2

Antitoxin

• AlphaFold DB: A1ART3