Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2101907..2102433 | Replicon | chromosome |
| Accession | NZ_CP084026 | ||
| Organism | Escherichia coli strain 035053C1pKPC2_Vir_090515B1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LC440_RS10230 | Protein ID | WP_000323025.1 |
| Coordinates | 2102146..2102433 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LC440_RS10225 | Protein ID | WP_000534858.1 |
| Coordinates | 2101907..2102146 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LC440_RS10170 (2096934) | 2096934..2097701 | - | 768 | Protein_1984 | exonuclease | - |
| LC440_RS10175 (2097794) | 2097794..2097985 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| LC440_RS10180 (2097982) | 2097982..2098170 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| LC440_RS10185 (2098738) | 2098738..2098956 | - | 219 | WP_001171942.1 | protein YdfC | - |
| LC440_RS24850 (2098986) | 2098986..2099114 | - | 129 | WP_000344964.1 | protein YdfB | - |
| LC440_RS10190 (2099116) | 2099116..2099271 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| LC440_RS10195 (2099438) | 2099438..2099845 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| LC440_RS10200 (2099929) | 2099929..2100159 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| LC440_RS10205 (2100143) | 2100143..2100421 | + | 279 | Protein_1992 | hypothetical protein | - |
| LC440_RS10210 (2100456) | 2100456..2100605 | + | 150 | WP_011443592.1 | protein YdfW | - |
| LC440_RS10215 (2101042) | 2101042..2101374 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| LC440_RS10220 (2101577) | 2101577..2101882 | - | 306 | WP_001326990.1 | protein YdfV | - |
| LC440_RS10225 (2101907) | 2101907..2102146 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LC440_RS10230 (2102146) | 2102146..2102433 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LC440_RS10235 (2102505) | 2102505..2102660 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| LC440_RS10240 (2102877) | 2102877..2103128 | + | 252 | WP_000980994.1 | protein Rem | - |
| LC440_RS10245 (2103195) | 2103195..2103473 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| LC440_RS10250 (2103475) | 2103475..2104524 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| LC440_RS10255 (2104538) | 2104538..2105290 | + | 753 | WP_001047135.1 | antitermination protein | - |
| LC440_RS10260 (2105568) | 2105568..2105657 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| LC440_RS10265 (2105712) | 2105712..2105924 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| LC440_RS10270 (2106225) | 2106225..2106440 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| LC440_RS10275 (2106804) | 2106804..2106974 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| LC440_RS10280 (2107194) | 2107194..2107409 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2091035..2132975 | 41940 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T217969 WP_000323025.1 NZ_CP084026:2102146-2102433 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T217969 NZ_CP114896:c2630938-2630642 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT217969 WP_000534858.1 NZ_CP084026:2101907-2102146 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT217969 NZ_CP114896:c2630640-2630245 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|