Detailed information of TA system TA217950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 4412622..4413153
• Replicon: chromosome
• Accession: NZ_CP084023
• Organism: Pectobacterium aroidearum strain LJ2

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A1V2R9S3
• Locus tag: LCF43_RS19875
• Protein ID: WP_012822123.1
• Coordinates: 4412622..4412909 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: -
• Locus tag: LCF43_RS19880
• Protein ID: WP_180778477.1
• Coordinates: 4412899..4413153 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCF43_RS19850	4407794..4407949	+	156	WP_012773032.1	hypothetical protein	-
LCF43_RS19855	4408084..4409475	+	1392	WP_205947214.1	outer membrane channel protein TolC	-
LCF43_RS19860	4409742..4410416	+	675	WP_012773030.1	DUF1190 family protein	-
LCF43_RS19865	4410428..4411588	+	1161	WP_180778474.1	glutathionylspermidine synthase family protein	-
LCF43_RS19870	4411658..4412443	-	786	WP_225181604.1	4,5-DOPA dioxygenase extradiol	-
LCF43_RS19875	4412622..4412909	-	288	WP_012822123.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LCF43_RS19880	4412899..4413153	-	255	WP_180778477.1	plasmid stabilization protein	Antitoxin
LCF43_RS19885	4413650..4414843	-	1194	WP_181848129.1	IS4 family transposase	-
LCF43_RS19895	4415363..4416250	-	888	WP_194431461.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4413650..4414843	1193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10997.94 Da
• Isoelectric Point: 10.7694

>T217950 WP_012822123.1 NZ_CP084023:c4412909-4412622 [Pectobacterium aroidearum]
MTYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQVYSDTKGRSA

Nucleotide

• Length: 288 bp

>T217950 NZ_CP114895:c3815710-3815414 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9240.44 Da
• Isoelectric Point: 3.7947

>AT217950 WP_180778477.1 NZ_CP084023:c4413153-4412899 [Pectobacterium aroidearum]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAMFAYLMELAEDAELGRTVDDRMSELADAEEIS
LDDL

Nucleotide

• Length: 255 bp

>AT217950 NZ_CP114895:c3815412-3815017 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• AlphaFold DB: A0A1V2R9S3