Detailed information of TA system TA021795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazE-MazF
• Location: 2634060..2634619
• Replicon: chromosome
• Accession: NC_008609
• Organism: Pelobacter propionicus DSM 2379

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A1ARS1
• Locus tag: PPRO_RS12055
• Protein ID: WP_011736297.1
• Coordinates: 2634060..2634305 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A1ARS2
• Locus tag: PPRO_RS12060
• Protein ID: WP_011736298.1
• Coordinates: 2634296..2634619 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PPRO_RS12025	2629626..2629943	+	318	WP_011736290.1	MoaD/ThiS family protein	-
PPRO_RS12030	2630354..2630707	+	354	WP_011736291.1	PilZ domain-containing protein	-
PPRO_RS12035	2631022..2631723	+	702	WP_011736292.1	CAAX prenyl protease-related protein	-
PPRO_RS12040	2631893..2632228	+	336	WP_011736293.1	nucleotidyltransferase domain-containing protein	-
PPRO_RS12045	2632215..2632616	+	402	WP_011736294.1	HEPN domain-containing protein	-
PPRO_RS12050	2632794..2633336	-	543	WP_083761328.1	PEP-CTERM sorting domain-containing protein	-
PPRO_RS12055	2634060..2634305	+	246	WP_011736297.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
PPRO_RS12060	2634296..2634619	+	324	WP_011736298.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
PPRO_RS12065	2634788..2636185	-	1398	WP_041532303.1	PEP-CTERM-box response regulator transcription factor	-
PPRO_RS12070	2636201..2638273	-	2073	WP_011736300.1	PEP-CTERM system histidine kinase PrsK	-
PPRO_RS12075	2638275..2639363	-	1089	WP_011736301.1	NAD-dependent epimerase/dehydratase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• SpoVT-AbrB domain (8-48)

Antitoxin

• mRNA interferase PemK-like (5-105)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9386.71 Da
• Isoelectric Point: 4.3023

>T21795 WP_011736297.1 NC_008609:2634060-2634305 [Pelobacter propionicus DSM 2379]
MLTHLVSIGNSKGIRIPAALLRQYDIIEEVELLPGKDEIVLRPVSRKPRNGWDEAFALMRERNEDALLTDDVLDLEEWEW
S

Nucleotide

• Length: 246 bp

>T21795 NC_008609:2634060-2634305 [Pelobacter propionicus DSM 2379]
ATGCTTACCCATCTCGTTTCCATCGGCAATTCAAAGGGCATCAGGATTCCTGCCGCGCTGCTGCGCCAGTACGACATCAT
CGAAGAGGTCGAACTGCTGCCCGGAAAAGACGAAATTGTGCTCCGCCCCGTATCCCGTAAACCGCGAAACGGATGGGACG
AGGCGTTTGCGCTTATGCGTGAACGCAACGAAGATGCCCTGCTGACGGACGATGTTCTCGACTTGGAGGAGTGGGAATGG
AGCTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12581.69 Da
• Isoelectric Point: 9.9953

>AT21795 WP_011736298.1 NC_008609:2634296-2634619 [Pelobacter propionicus DSM 2379]
MELNQYHVYLVNLDPTIGHEIQKTRPCVVISPDEMNRHLKTVMIAPMTTKSHDYPSRVELRFSGTRAWIVLDQIRTVDRA
RLVRELGKLNLRQISRVKETIREMLVD

Nucleotide

• Length: 324 bp

>AT21795 NC_008609:2634296-2634619 [Pelobacter propionicus DSM 2379]
ATGGAGCTGAATCAGTATCATGTCTATCTGGTCAATCTGGATCCGACGATCGGACACGAGATCCAGAAGACCCGTCCCTG
TGTGGTCATTTCTCCAGATGAAATGAACCGCCACCTGAAAACCGTCATGATCGCGCCCATGACGACCAAATCCCACGACT
ATCCCAGCCGGGTGGAACTGCGCTTCAGCGGCACGCGGGCATGGATCGTTCTTGACCAGATACGGACCGTGGACCGCGCG
CGTCTGGTCAGGGAACTGGGCAAACTCAACCTGCGCCAGATCAGCAGGGTAAAAGAAACCATCAGGGAGATGCTCGTCGA
CTGA

Structures

Toxin

• AlphaFold DB: A1ARS1

Antitoxin

• AlphaFold DB: A1ARS2