Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4013128..4013788 Replicon chromosome
Accession NZ_CP084023
Organism Pectobacterium aroidearum strain LJ2

Toxin (Protein)


Gene name cptA Uniprot ID A0A7W2E4X8
Locus tag LCF43_RS18120 Protein ID WP_012773341.1
Coordinates 4013128..4013541 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C6D8Y5
Locus tag LCF43_RS18125 Protein ID WP_012773340.1
Coordinates 4013522..4013788 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCF43_RS18095 4008505..4009404 - 900 WP_180777499.1 site-specific tyrosine recombinase XerD -
LCF43_RS18100 4009716..4011044 + 1329 WP_181845156.1 MFS transporter -
LCF43_RS18105 4011207..4011725 + 519 WP_012773344.1 flavodoxin FldB -
LCF43_RS18110 4011754..4012077 + 324 WP_181847019.1 hypothetical protein -
LCF43_RS18115 4012123..4013058 - 936 WP_225181483.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
LCF43_RS18120 4013128..4013541 - 414 WP_012773341.1 protein YgfX Toxin
LCF43_RS18125 4013522..4013788 - 267 WP_012773340.1 FAD assembly factor SdhE Antitoxin
LCF43_RS18130 4014024..4015025 + 1002 WP_194431591.1 tRNA-modifying protein YgfZ -
LCF43_RS18135 4015082..4015729 - 648 WP_225181484.1 hemolysin III family protein -
LCF43_RS18140 4016142..4016750 + 609 WP_194431590.1 HD domain-containing protein -
LCF43_RS18145 4016826..4018148 - 1323 WP_194431758.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16302.21 Da        Isoelectric Point: 10.6525

>T217946 WP_012773341.1 NZ_CP084023:c4013541-4013128 [Pectobacterium aroidearum]
VAQWQCDLRVSWRMQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Download         Length: 414 bp

>T217946 NZ_CP114895:3407104-3408177 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10465.94 Da        Isoelectric Point: 6.2223

>AT217946 WP_012773340.1 NZ_CP084023:c4013788-4013522 [Pectobacterium aroidearum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT217946 NZ_CP114895:3408170-3408541 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E4X8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E501

References