Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 214994..215611 Replicon chromosome
Accession NZ_CP084023
Organism Pectobacterium aroidearum strain LJ2

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag LCF43_RS00935 Protein ID WP_010281507.1
Coordinates 215432..215611 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LCF43_RS00930 Protein ID WP_180779155.1
Coordinates 214994..215404 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCF43_RS00915 210818..211861 - 1044 WP_012772905.1 DNA-binding transcriptional regulator CytR -
LCF43_RS00920 212138..214336 - 2199 WP_181847420.1 primosomal protein N' -
LCF43_RS00925 214652..214867 + 216 WP_012772907.1 50S ribosomal protein L31 -
LCF43_RS00930 214994..215404 - 411 WP_180779155.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LCF43_RS00935 215432..215611 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
LCF43_RS00940 215709..216719 - 1011 WP_012772909.1 iron ABC transporter permease -
LCF43_RS00945 216716..217678 - 963 WP_181847424.1 ABC transporter substrate-binding protein -
LCF43_RS00950 217688..218485 - 798 WP_225181793.1 ABC transporter ATP-binding protein -
LCF43_RS00955 218701..219018 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
LCF43_RS00960 219206..220366 + 1161 WP_012772912.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T217942 WP_010281507.1 NZ_CP084023:c215611-215432 [Pectobacterium aroidearum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T217942 NZ_CP114895:c2564462-2564359 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14492.36 Da        Isoelectric Point: 4.3391

>AT217942 WP_180779155.1 NZ_CP084023:c215404-214994 [Pectobacterium aroidearum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLVEMGQDIPTVSTVGQLAKGSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT217942 NZ_CP114895:2564321-2564592 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure

References