Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 177968..178602 Replicon chromosome
Accession NZ_CP084023
Organism Pectobacterium aroidearum strain LJ2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LCF43_RS00765 Protein ID WP_181845733.1
Coordinates 177968..178243 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LCF43_RS00770 Protein ID WP_181830203.1
Coordinates 178240..178602 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCF43_RS00750 174989..176359 - 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -
LCF43_RS00755 176356..177054 - 699 WP_012772878.1 envelope stress response regulator transcription factor CpxR -
LCF43_RS00760 177208..177732 + 525 WP_225181785.1 cell-envelope stress modulator CpxP -
LCF43_RS00765 177968..178243 + 276 WP_181845733.1 type II toxin-antitoxin system HicA family toxin Toxin
LCF43_RS00770 178240..178602 + 363 WP_181830203.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LCF43_RS00775 178977..180164 + 1188 WP_180779137.1 sugar transporter -
LCF43_RS00780 180208..181110 + 903 WP_012772881.1 CDF family cation-efflux transporter FieF -
LCF43_RS00785 181318..182280 + 963 WP_012772882.1 6-phosphofructokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10051.64 Da        Isoelectric Point: 11.1875

>T217941 WP_181845733.1 NZ_CP084023:177968-178243 [Pectobacterium aroidearum]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVNL
REWLESIGVKP

Download         Length: 276 bp

>T217941 NZ_CP114895:c2285942-2285655 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13577.41 Da        Isoelectric Point: 4.4981

>AT217941 WP_181830203.1 NZ_CP084023:178240-178602 [Pectobacterium aroidearum]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRNEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLNERMKQA

Download         Length: 363 bp

>AT217941 NZ_CP114895:c2286181-2285942 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References