Detailed information of TA system TA021794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TacT2-ataR/DUF1778(antitoxin)
• Location: 1436147..1436940
• Replicon: chromosome
• Accession: NC_008609
• Organism: Pelobacter propionicus DSM 2379

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A1ANQ3
• Locus tag: PPRO_RS06720
• Protein ID: WP_011735266.1
• Coordinates: 1436147..1436653 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: PPRO_RS06725
• Protein ID: WP_041532185.1
• Coordinates: 1436653..1436940 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PPRO_RS06700	1431831..1433570	+	1740	WP_011735263.1	30S ribosomal protein S1	-
PPRO_RS06705	1433597..1433875	+	279	WP_011735264.1	integration host factor subunit beta	-
PPRO_RS06715	1434610..1435899	-	1290	WP_011735265.1	geopeptide radical SAM maturase	-
PPRO_RS06720	1436147..1436653	-	507	WP_011735266.1	GNAT family N-acetyltransferase	Toxin
PPRO_RS06725	1436653..1436940	-	288	WP_041532185.1	DUF1778 domain-containing protein	Antitoxin
PPRO_RS06730	1437027..1437986	-	960	WP_011735268.1	transposase	-
PPRO_RS06735	1438163..1439059	-	897	WP_011735269.1	geopeptide radical SAM maturase	-
PPRO_RS06740	1439590..1441404	+	1815	WP_198138337.1	TonB-dependent receptor plug domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-142)

Antitoxin

• Vibrio phage ICP1, Orf50 (16-88)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18055.81 Da
• Isoelectric Point: 8.5121

>T21794 WP_011735266.1 NC_008609:c1436653-1436147 [Pelobacter propionicus DSM 2379]
MISAPALLTREHHTGSFSCGVASLDDWLRHRAYSNQVSGASRTYVAAEGQRVVGYYCLASGALAVSDTPGPLRRNMPDPV
PMAILGRLAVDRDFHRKGLGVALLQDAVIRTMQAGGILGIRGLLVHAISEEAKMFYEHHGFIASPTQPMTLTLSLKGMVS
PQQPEMSG

Nucleotide

• Length: 507 bp

>T21794 NC_008609:c1436653-1436147 [Pelobacter propionicus DSM 2379]
ATGATATCAGCTCCGGCACTGCTGACGAGAGAGCACCACACCGGCAGCTTTTCCTGCGGCGTTGCCAGTCTGGACGACTG
GCTGCGACACCGGGCATATTCCAACCAGGTAAGCGGAGCTTCCCGTACCTATGTTGCAGCGGAAGGGCAACGTGTTGTCG
GCTATTACTGTTTGGCATCCGGAGCGCTGGCGGTAAGCGATACACCCGGGCCTCTTCGGCGCAACATGCCCGATCCGGTT
CCCATGGCCATTCTTGGACGCCTGGCCGTTGATCGTGATTTTCACCGCAAGGGACTCGGCGTTGCGCTGCTCCAGGATGC
CGTTATCAGAACGATGCAGGCGGGCGGAATTCTCGGAATTCGAGGTTTGCTCGTCCATGCCATATCCGAAGAAGCCAAGA
TGTTCTATGAACACCACGGCTTCATTGCCTCCCCCACGCAACCGATGACCCTGACACTCTCGCTGAAGGGTATGGTGTCG
CCACAGCAGCCAGAAATGTCCGGCTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10711.99 Da
• Isoelectric Point: 6.4635

>AT21794 WP_041532185.1 NC_008609:c1436940-1436653 [Pelobacter propionicus DSM 2379]
MPSTSPETDSRTCAVNLRVRGDIRALIDRAAKTQGKTRSDFMIDAARRAAEDAVLDQTLVRVDRETYEHFLQALDHPPSG
EGFNRLMQASRPWEP

Nucleotide

• Length: 288 bp

>AT21794 NC_008609:c1436940-1436653 [Pelobacter propionicus DSM 2379]
ATGCCATCGACCTCACCAGAAACTGACAGCCGAACCTGTGCCGTAAATCTGCGCGTACGGGGCGATATCCGAGCCTTGAT
TGACAGGGCGGCGAAGACACAGGGGAAAACACGCTCGGATTTCATGATCGATGCGGCACGGCGGGCGGCCGAGGATGCAG
TGCTTGACCAGACCCTGGTGCGAGTGGATCGTGAAACATACGAGCACTTTCTCCAAGCTCTCGACCATCCCCCCAGTGGC
GAAGGGTTTAACCGCCTGATGCAGGCCAGCAGGCCGTGGGAGCCGTAA

Structures

Toxin

• AlphaFold DB: A1ANQ3