Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1620165..1620754 Replicon chromosome
Accession NZ_CP084020
Organism Bifidobacterium longum subsp. longum strain NBRC 114494

Toxin (Protein)


Gene name PumA Uniprot ID B3DQN5
Locus tag LCQ52_RS07335 Protein ID WP_010080907.1
Coordinates 1620165..1620473 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag LCQ52_RS07340 Protein ID WP_007057517.1
Coordinates 1620470..1620754 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCQ52_RS07320 (LCQ52_07320) 1615910..1619029 - 3120 WP_225724213.1 alpha-mannosidase -
LCQ52_RS07325 (LCQ52_07325) 1619190..1619678 - 489 WP_131202859.1 D-aminoacyl-tRNA deacylase -
LCQ52_RS07330 (LCQ52_07330) 1619699..1620133 + 435 WP_225724214.1 DUF1922 domain-containing protein -
LCQ52_RS07335 (LCQ52_07335) 1620165..1620473 + 309 WP_010080907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCQ52_RS07340 (LCQ52_07340) 1620470..1620754 + 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
LCQ52_RS07350 (LCQ52_07350) 1621001..1621183 + 183 WP_225724532.1 phage holin -
LCQ52_RS07360 (LCQ52_07360) 1622015..1622944 - 930 WP_225724215.1 FtsQ-type POTRA domain-containing protein -
LCQ52_RS07365 (LCQ52_07365) 1623079..1624617 - 1539 WP_225724216.1 UDP-N-acetylmuramate--L-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-94)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11610.38 Da        Isoelectric Point: 10.3171

>T217939 WP_010080907.1 NZ_CP084020:1620165-1620473 [Bifidobacterium longum subsp. longum]
MEIKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDK
STQQTDIRQAHDILNDYKEQRQ

Download         Length: 309 bp

>T217939 NZ_CP114895:2150566-2150742 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT217939 WP_007057517.1 NZ_CP084020:1620470-1620754 [Bifidobacterium longum subsp. longum]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp

>AT217939 NZ_CP114895:2150788-2151204 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0U788

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References