Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 1750054..1750662 | Replicon | chromosome |
| Accession | NZ_CP084012 | ||
| Organism | Bifidobacterium longum strain NBRC 114370 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | I3BGL7 |
| Locus tag | LCQ81_RS07435 | Protein ID | WP_007056255.1 |
| Coordinates | 1750054..1750389 (-) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | I3BGP0 |
| Locus tag | LCQ81_RS07440 | Protein ID | WP_007056990.1 |
| Coordinates | 1750393..1750662 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCQ81_RS11570 | 1745196..1745504 | + | 309 | Protein_1421 | hypothetical protein | - |
| LCQ81_RS07390 (LCQ81_07390) | 1745543..1745791 | + | 249 | WP_200434522.1 | hypothetical protein | - |
| LCQ81_RS07395 (LCQ81_07395) | 1745927..1746547 | + | 621 | WP_007054239.1 | NUDIX hydrolase | - |
| LCQ81_RS07400 (LCQ81_07400) | 1746540..1746899 | + | 360 | WP_224743519.1 | nitrilase-related carbon-nitrogen hydrolase | - |
| LCQ81_RS07405 (LCQ81_07405) | 1747063..1747209 | - | 147 | WP_007056267.1 | hypothetical protein | - |
| LCQ81_RS07410 (LCQ81_07410) | 1747549..1747842 | - | 294 | WP_012471870.1 | hypothetical protein | - |
| LCQ81_RS07415 (LCQ81_07415) | 1747935..1748576 | - | 642 | WP_007056262.1 | hypothetical protein | - |
| LCQ81_RS07420 (LCQ81_07420) | 1748790..1748969 | + | 180 | WP_007056286.1 | antitoxin VbhA family protein | - |
| LCQ81_RS07425 (LCQ81_07425) | 1748966..1749550 | + | 585 | WP_007056278.1 | Fic family protein | - |
| LCQ81_RS07430 (LCQ81_07430) | 1749753..1750037 | - | 285 | WP_007056282.1 | hypothetical protein | - |
| LCQ81_RS07435 (LCQ81_07435) | 1750054..1750389 | - | 336 | WP_007056255.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| LCQ81_RS07440 (LCQ81_07440) | 1750393..1750662 | - | 270 | WP_007056990.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LCQ81_RS07445 (LCQ81_07445) | 1750847..1752007 | - | 1161 | WP_032736233.1 | ABC transporter permease | - |
| LCQ81_RS07450 (LCQ81_07450) | 1752013..1752693 | - | 681 | WP_131206469.1 | ABC transporter ATP-binding protein | - |
| LCQ81_RS07455 (LCQ81_07455) | 1752690..1753580 | - | 891 | WP_007056280.1 | hypothetical protein | - |
| LCQ81_RS07460 (LCQ81_07460) | 1753577..1754095 | - | 519 | WP_224743518.1 | hypothetical protein | - |
| LCQ81_RS07465 (LCQ81_07465) | 1754227..1754913 | + | 687 | WP_013140734.1 | response regulator transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1725836..1765718 | 39882 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12650.60 Da Isoelectric Point: 9.1088
>T217933 WP_007056255.1 NZ_CP084012:c1750389-1750054 [Bifidobacterium longum]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELFGQIAGLHPALNQPTAI
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELFGQIAGLHPALNQPTAI
Download Length: 336 bp
>T217933 NZ_CP114895:c902918-902577 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9844.16 Da Isoelectric Point: 4.5742
>AT217933 WP_007056990.1 NZ_CP084012:c1750662-1750393 [Bifidobacterium longum]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI
Download Length: 270 bp
>AT217933 NZ_CP114895:c903256-902939 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|