Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1986377..1986886 Replicon chromosome
Accession NZ_CP084008
Organism Staphylococcus epidermidis strain NBRC 113846

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag LCR03_RS09265 Protein ID WP_001829980.1
Coordinates 1986377..1986586 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag LCR03_RS09270 Protein ID WP_001829893.1
Coordinates 1986593..1986886 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCR03_RS09245 (LCR03_09245) 1981955..1983310 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LCR03_RS09250 (LCR03_09250) 1983322..1984395 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
LCR03_RS09255 (LCR03_09255) 1984786..1985997 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
LCR03_RS09260 (LCR03_09260) 1986097..1986234 - 138 WP_001829949.1 Lmo0850 family protein -
LCR03_RS09265 (LCR03_09265) 1986377..1986586 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
LCR03_RS09270 (LCR03_09270) 1986593..1986886 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
LCR03_RS09275 (LCR03_09275) 1987060..1988544 + 1485 WP_001829964.1 cardiolipin synthase -
LCR03_RS09280 (LCR03_09280) 1988726..1989379 + 654 WP_001829983.1 HD domain-containing protein -
LCR03_RS09285 (LCR03_09285) 1989485..1990357 - 873 WP_001832740.1 membrane protein insertase YidC -
LCR03_RS09290 (LCR03_09290) 1990446..1991084 - 639 WP_225088279.1 thiamine phosphate synthase -
LCR03_RS09295 (LCR03_09295) 1991090..1991878 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T217931 WP_001829980.1 NZ_CP084008:c1986586-1986377 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T217931 NZ_CP114895:c886264-885986 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT217931 WP_001829893.1 NZ_CP084008:c1986886-1986593 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT217931 NZ_CP114895:c886527-886267 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References