Detailed information of TA system TA021793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 11895..12697
• Replicon: plasmid pPRO2
• Accession: NC_008608
• Organism: Pelobacter propionicus DSM 2379

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: PPRO_RS20545
• Protein ID: WP_011733944.1
• Coordinates: 11895..12422 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: A0R860
• Locus tag: PPRO_RS19075
• Protein ID: WP_011733945.1
• Coordinates: 12419..12697 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PPRO_RS19045	7044..7754	-	711	WP_011733938.1	ABC transporter ATP-binding protein	-
PPRO_RS19050	7756..8961	-	1206	WP_011733939.1	ABC transporter permease	-
PPRO_RS19055	8958..10109	-	1152	WP_011733940.1	efflux RND transporter periplasmic adaptor subunit	-
PPRO_RS19060	10106..10714	-	609	WP_011733941.1	TetR/AcrR family transcriptional regulator	-
PPRO_RS19065	10973..11254	-	282	WP_041533075.1	HigA family addiction module antidote protein	-
PPRO_RS20540	11277..11555	-	279	WP_011733943.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PPRO_RS20545	11895..12422	-	528	WP_011733944.1	GNAT family N-acetyltransferase	Toxin
PPRO_RS19075	12419..12697	-	279	WP_011733945.1	DUF1778 domain-containing protein	Antitoxin
PPRO_RS19085	13713..14495	+	783	WP_157040166.1	pirin	-
PPRO_RS19090	14980..15234	+	255	WP_011733948.1	ribbon-helix-helix domain-containing protein	-
PPRO_RS19095	15218..15499	+	282	WP_011733949.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PPRO_RS19100	15731..16123	-	393	WP_157040165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..30722	30722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (11-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19085.83 Da
• Isoelectric Point: 8.7489

>T21793 WP_011733944.1 NC_008608:c12422-11895 [Pelobacter propionicus DSM 2379]
MTISPWHEEPISKQHNREAFDCGNAALNDFLRRHARQTHEHGGAKTFVAVSDDNPSLVFGFYSLSPASVEFSRTPSIITR
GLARHDVPVFRLCRLAVDRTMQSKGLGGQLLLSAGRRCLRASQEVGGVALLIDAKNESVAHWYTNYGALPLLDIPLSLLL
PLSTIQAALNAAGKL

Nucleotide

• Length: 528 bp

>T21793 NC_008608:c12422-11895 [Pelobacter propionicus DSM 2379]
ATGACGATTTCCCCTTGGCATGAAGAGCCGATTTCCAAACAGCATAACCGAGAAGCATTTGATTGCGGCAATGCCGCATT
AAATGATTTCCTACGCCGACATGCACGACAAACGCACGAACACGGGGGCGCTAAAACCTTCGTGGCAGTCAGTGATGATA
ATCCGTCATTGGTTTTTGGCTTCTATTCTCTTAGTCCCGCCTCTGTTGAGTTTTCCCGTACTCCCTCTATCATCACGCGC
GGATTGGCTCGGCATGACGTGCCTGTCTTCCGCCTTTGTCGTCTGGCGGTTGATCGGACTATGCAAAGCAAGGGGCTGGG
TGGTCAACTTCTTCTGTCCGCCGGTAGGCGCTGCCTTCGCGCCTCGCAAGAGGTCGGAGGCGTGGCATTATTGATCGACG
CCAAGAACGAGAGCGTCGCGCATTGGTACACCAATTATGGCGCTTTGCCTCTTCTAGATATACCGCTTTCTCTGCTTCTG
CCGCTATCGACCATCCAAGCGGCGTTAAACGCTGCCGGAAAACTATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10141.71 Da
• Isoelectric Point: 9.9233

>AT21793 WP_011733945.1 NC_008608:c12697-12419 [Pelobacter propionicus DSM 2379]
MPRVAVKENNRMSLRIRPNDKALLMRAVSYTHTDLTDFVLKNALQAAKDVIAQAEQVSLSERDSLRVLDALENPPSPNSK
LLAAAHALPVQP

Nucleotide

• Length: 279 bp

>AT21793 NC_008608:c12697-12419 [Pelobacter propionicus DSM 2379]
ATGCCAAGAGTGGCCGTAAAAGAGAACAATCGAATGTCTTTGAGAATCCGCCCGAATGATAAGGCGCTGCTGATGCGTGC
CGTTTCCTATACGCATACCGACCTTACGGATTTTGTACTGAAAAACGCCTTGCAAGCGGCAAAGGATGTGATCGCCCAGG
CTGAACAGGTTTCACTGTCAGAGCGCGACAGCTTGCGTGTATTGGATGCTTTGGAAAATCCGCCTTCTCCGAATTCAAAA
CTGCTGGCGGCGGCTCATGCCTTGCCTGTGCAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0R860