Detailed information of TA system TA217929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1828255..1829057
• Replicon: chromosome
• Accession: NZ_CP084008
• Organism: Staphylococcus epidermidis strain NBRC 113846

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: LCR03_RS08365
• Protein ID: WP_002468490.1
• Coordinates: 1828255..1828434 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: LCR03_RS08370
• Protein ID: WP_002486232.1
• Coordinates: 1828458..1829057 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCR03_RS08345 (LCR03_08345)	1823648..1824781	-	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-
LCR03_RS08350 (LCR03_08350)	1824940..1825764	+	825	WP_001829804.1	RluA family pseudouridine synthase	-
LCR03_RS08355 (LCR03_08355)	1826125..1827510	-	1386	WP_001829862.1	class II fumarate hydratase	-
LCR03_RS08360 (LCR03_08360)	1827695..1828099	-	405	WP_002485605.1	hypothetical protein	-
LCR03_RS08365 (LCR03_08365)	1828255..1828434	-	180	WP_002468490.1	SAS053 family protein	Toxin
LCR03_RS08370 (LCR03_08370)	1828458..1829057	-	600	WP_002486232.1	glucosamine-6-phosphate isomerase	Antitoxin
LCR03_RS08375 (LCR03_08375)	1829215..1829685	-	471	WP_001829836.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LCR03_RS08380 (LCR03_08380)	1829682..1830812	-	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
LCR03_RS11990	1831027..1831158	-	132	WP_255264851.1	hypothetical protein	-
LCR03_RS08385 (LCR03_08385)	1831673..1832395	-	723	WP_001829838.1	amino acid ABC transporter ATP-binding protein	-
LCR03_RS08390 (LCR03_08390)	1832388..1833845	-	1458	WP_002440300.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T217929 WP_002468490.1 NZ_CP084008:c1828434-1828255 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T217929 NZ_CP114895:525523-525873 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22695.55 Da
• Isoelectric Point: 4.8641

>AT217929 WP_002486232.1 NZ_CP084008:c1829057-1828458 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT217929 NZ_CP114895:525278-525529 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A2G7HY44