Detailed information of TA system TA217928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 869832..870302
• Replicon: chromosome
• Accession: NZ_CP084008
• Organism: Staphylococcus epidermidis strain NBRC 113846

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: LCR03_RS03965
• Protein ID: WP_001829569.1
• Coordinates: 869832..870020 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: LCR03_RS03970
• Protein ID: WP_002438963.1
• Coordinates: 870045..870302 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCR03_RS03935 (LCR03_03935)	866313..866513	+	201	WP_001829681.1	cold-shock protein	-
LCR03_RS03940 (LCR03_03940)	867134..867358	-	225	WP_001829613.1	hypothetical protein	-
LCR03_RS03945 (LCR03_03945)	867382..867666	-	285	WP_001829635.1	hypothetical protein	-
LCR03_RS03950 (LCR03_03950)	867765..868511	-	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
LCR03_RS03955 (LCR03_03955)	868795..869028	+	234	WP_001829664.1	hypothetical protein	-
LCR03_RS03960 (LCR03_03960)	869088..869642	-	555	WP_002469327.1	lipoprotein N-acylation protein LnsA	-
LCR03_RS03965 (LCR03_03965)	869832..870020	-	189	WP_001829569.1	hypothetical protein	Toxin
LCR03_RS03970 (LCR03_03970)	870045..870302	-	258	WP_002438963.1	hypothetical protein	Antitoxin
LCR03_RS03975 (LCR03_03975)	870710..870913	+	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
LCR03_RS03980 (LCR03_03980)	870905..871141	-	237	WP_002457224.1	hypothetical protein	-
LCR03_RS03985 (LCR03_03985)	871355..871942	+	588	WP_002469329.1	histidine phosphatase family protein	-
LCR03_RS03990 (LCR03_03990)	872213..872713	-	501	WP_001829623.1	GNAT family N-acetyltransferase	-
LCR03_RS03995 (LCR03_03995)	873099..873286	+	188	Protein_772	hypothetical protein	-
LCR03_RS04000 (LCR03_04000)	873316..873453	+	138	WP_162161215.1	hypothetical protein	-
LCR03_RS04005 (LCR03_04005)	873637..874059	-	423	WP_002457221.1	organic hydroperoxide resistance protein	-
LCR03_RS04010 (LCR03_04010)	874220..874936	+	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	873298..873453	155
	-	inside	Prophage	-	-	852289..879328	27039

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T217928 WP_001829569.1 NZ_CP084008:c870020-869832 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T217928 NZ_CP114895:429739-429912 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT217928 WP_002438963.1 NZ_CP084008:c870302-870045 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT217928 NZ_CP114895:429415-429711 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3