Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1053975..1054521 Replicon chromosome
Accession NZ_CP084007
Organism Flavonifractor plautii strain NBRC 113805

Toxin (Protein)


Gene name relE Uniprot ID A0A6I2RGN4
Locus tag LCR02_RS05390 Protein ID WP_024724286.1
Coordinates 1054249..1054521 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6I2RLP7
Locus tag LCR02_RS05385 Protein ID WP_024724287.1
Coordinates 1053975..1054256 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCR02_RS05365 (LCR02_05365) 1049243..1049959 + 717 WP_024724290.1 response regulator transcription factor -
LCR02_RS05370 (LCR02_05370) 1050258..1050776 + 519 WP_024724289.1 sigma-70 family RNA polymerase sigma factor -
LCR02_RS05375 (LCR02_05375) 1051020..1051751 + 732 Protein_1048 exodeoxyribonuclease III -
LCR02_RS05380 (LCR02_05380) 1051806..1053863 + 2058 WP_225123536.1 reverse transcriptase domain-containing protein -
LCR02_RS05385 (LCR02_05385) 1053975..1054256 + 282 WP_024724287.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LCR02_RS05390 (LCR02_05390) 1054249..1054521 + 273 WP_024724286.1 type II toxin-antitoxin system YafQ family toxin Toxin
LCR02_RS05395 (LCR02_05395) 1055179..1056348 + 1170 WP_024724285.1 C39 family peptidase -
LCR02_RS05400 (LCR02_05400) 1056345..1056839 + 495 WP_024724284.1 hypothetical protein -
LCR02_RS05405 (LCR02_05405) 1057355..1057567 - 213 WP_051410322.1 hypothetical protein -
LCR02_RS05410 (LCR02_05410) 1057579..1059174 - 1596 WP_024724283.1 hypothetical protein -
LCR02_RS05415 (LCR02_05415) 1059304..1059519 - 216 WP_034566378.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1050258..1090903 40645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-87)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10496.04 Da        Isoelectric Point: 7.8785

>T217927 WP_024724286.1 NZ_CP084007:1054249-1054521 [Flavonifractor plautii]
MYNIRPTTKFQRDLKRVKRRGFDISLLTDIIKKLAAGEPLPEKNRDHQMSGDYAGCRECHITPDWLLIYEVDGNELILYL
TRTGSHSDLF

Download         Length: 273 bp

>T217927 NZ_CP114894:c4375549-4375331 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10541.09 Da        Isoelectric Point: 4.4692

>AT217927 WP_024724287.1 NZ_CP084007:1053975-1054256 [Flavonifractor plautii]
MANTNINIRMDTDLKKQFEAFCADMGMTMTTAFNIFARKAVREYRIPFEISGDVPNAETVEAIQEVKRMKANPSLGKTYS
DVDQMIEELLADV

Download         Length: 282 bp

>AT217927 NZ_CP114894:c4375949-4375575 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I2RGN4

Antitoxin

Source ID Structure
AlphaFold DB A0A6I2RLP7

References