Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4175899..4176680 Replicon chromosome
Accession NZ_CP084001
Organism Salmonella sp. A7

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag LCS67_RS20370 Protein ID WP_000625912.1
Coordinates 4175899..4176390 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag LCS67_RS20375 Protein ID WP_001110453.1
Coordinates 4176387..4176680 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCS67_RS20345 (4171034) 4171034..4173472 - 2439 WP_079971608.1 F4 (K88) fimbrial usher FaeD -
LCS67_RS20350 (4173482) 4173482..4174021 - 540 WP_000721295.1 type 1 fimbrial protein -
LCS67_RS20355 (4174056) 4174056..4174340 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
LCS67_RS20360 (4174933) 4174933..4175160 + 228 WP_001112992.1 hypothetical protein -
LCS67_RS20365 (4175436) 4175436..4175684 - 249 Protein_3979 IS481 family transposase -
LCS67_RS20370 (4175899) 4175899..4176390 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
LCS67_RS20375 (4176387) 4176387..4176680 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
LCS67_RS20380 (4176997) 4176997..4177219 + 223 Protein_3982 hypothetical protein -
LCS67_RS20385 (4177483) 4177483..4178358 + 876 WP_000921676.1 AraC family transcriptional regulator -
LCS67_RS20390 (4178355) 4178355..4178642 + 288 WP_001269916.1 transcriptional regulator RtsB -
LCS67_RS20395 (4178635) 4178635..4178817 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
LCS67_RS20400 (4178837) 4178837..4178936 + 100 Protein_3986 hypothetical protein -
LCS67_RS20405 (4179046) 4179046..4179180 + 135 Protein_3987 hypothetical protein -
LCS67_RS20410 (4179475) 4179475..4180380 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4164289..4178642 14353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T217923 WP_000625912.1 NZ_CP084001:c4176390-4175899 [Salmonella sp. A7]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T217923 NZ_CP114894:c3901836-3901579 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT217923 WP_001110453.1 NZ_CP084001:c4176680-4176387 [Salmonella sp. A7]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT217923 NZ_CP114894:c3901567-3901022 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References