217922

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4038119..4038635 Replicon chromosome
Accession NZ_CP084001
Organism Salmonella sp. A7

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LCS67_RS19645 Protein ID WP_000220578.1
Coordinates 4038119..4038403 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LCS67_RS19650 Protein ID WP_000212724.1
Coordinates 4038393..4038635 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCS67_RS19630 (4033941) 4033941..4034681 + 741 WP_223202802.1 GIY-YIG nuclease family protein -
LCS67_RS19635 (4035296) 4035296..4037434 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
LCS67_RS19640 (4037651) 4037651..4038115 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LCS67_RS19645 (4038119) 4038119..4038403 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCS67_RS19650 (4038393) 4038393..4038635 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LCS67_RS19655 (4038713) 4038713..4040626 - 1914 WP_001212131.1 BglG family transcription antiterminator -
LCS67_RS19660 (4040643) 4040643..4041383 - 741 WP_000779263.1 KDGP aldolase family protein -
LCS67_RS19665 (4041380) 4041380..4042498 - 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LCS67_RS19670 (4042482) 4042482..4043615 - 1134 WP_023212816.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T217922 WP_000220578.1 NZ_CP084001:c4038403-4038119 [Salmonella sp. A7]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T217922 NZ_CP114894:3815030-3815380 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT217922 WP_000212724.1 NZ_CP084001:c4038635-4038393 [Salmonella sp. A7]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT217922 NZ_CP114894:3814785-3815036 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References