Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3995177..3995727 Replicon chromosome
Accession NZ_CP084001
Organism Salmonella sp. A7

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LCS67_RS19420 Protein ID WP_001199743.1
Coordinates 3995177..3995485 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag LCS67_RS19425 Protein ID WP_000016244.1
Coordinates 3995488..3995727 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCS67_RS19410 (3990564) 3990564..3994079 - 3516 WP_000342547.1 AAA domain-containing protein -
LCS67_RS19415 (3994441) 3994441..3994742 - 302 Protein_3796 Arm DNA-binding domain-containing protein -
LCS67_RS19420 (3995177) 3995177..3995485 - 309 WP_001199743.1 CcdB family protein Toxin
LCS67_RS19425 (3995488) 3995488..3995727 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LCS67_RS19430 (3995836) 3995836..3996060 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
LCS67_RS19445 (3996845) 3996845..3997864 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
LCS67_RS19450 (3997892) 3997892..3998422 - 531 WP_000896758.1 gluconokinase -
LCS67_RS19455 (3998639) 3998639..3999670 + 1032 WP_000453343.1 L-idonate 5-dehydrogenase -
LCS67_RS19460 (3999695) 3999695..4000459 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T217921 WP_001199743.1 NZ_CP084001:c3995485-3995177 [Salmonella sp. A7]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T217921 NZ_CP114894:3719246-3719419 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT217921 WP_000016244.1 NZ_CP084001:c3995727-3995488 [Salmonella sp. A7]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT217921 NZ_CP114894:3718922-3719218 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References