Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3313028..3313648 Replicon chromosome
Accession NZ_CP084001
Organism Salmonella sp. A7

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LCS67_RS16275 Protein ID WP_001280991.1
Coordinates 3313430..3313648 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LCS67_RS16270 Protein ID WP_000344807.1
Coordinates 3313028..3313402 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCS67_RS16260 (3308167) 3308167..3309360 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LCS67_RS16265 (3309383) 3309383..3312532 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LCS67_RS16270 (3313028) 3313028..3313402 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LCS67_RS16275 (3313430) 3313430..3313648 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LCS67_RS16280 (3313827) 3313827..3314378 + 552 WP_001278786.1 maltose O-acetyltransferase -
LCS67_RS16285 (3314495) 3314495..3314965 + 471 WP_000136183.1 YlaC family protein -
LCS67_RS16290 (3315020) 3315020..3315160 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LCS67_RS16295 (3315166) 3315166..3315426 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LCS67_RS16300 (3315651) 3315651..3317201 + 1551 WP_000213131.1 EAL domain-containing protein -
LCS67_RS16310 (3317432) 3317432..3317821 + 390 WP_000961285.1 MGMT family protein -
LCS67_RS16315 (3317854) 3317854..3318423 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T217920 WP_001280991.1 NZ_CP084001:3313430-3313648 [Salmonella sp. A7]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T217920 NZ_CP114894:c3063030-3062923 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT217920 WP_000344807.1 NZ_CP084001:3313028-3313402 [Salmonella sp. A7]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT217920 NZ_CP114894:3063078-3063144 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References