Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2397192..2398167 | Replicon | chromosome |
| Accession | NC_008600 | ||
| Organism | Bacillus thuringiensis str. Al Hakam | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | C2NHW3 |
| Locus tag | BALH_RS12440 | Protein ID | WP_002002796.1 |
| Coordinates | 2397192..2397929 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | BALH_RS12445 | Protein ID | WP_000588712.1 |
| Coordinates | 2398042..2398167 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BALH_RS12415 | 2392684..2393385 | + | 702 | WP_001294994.1 | hypothetical protein | - |
| BALH_RS12420 | 2393513..2394397 | + | 885 | WP_000795513.1 | hypothetical protein | - |
| BALH_RS12425 | 2394690..2395509 | - | 820 | Protein_2343 | alpha-keto acid decarboxylase family protein | - |
| BALH_RS12430 | 2395616..2396098 | + | 483 | WP_000191909.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| BALH_RS12435 | 2396266..2397003 | + | 738 | WP_000594157.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| BALH_RS12440 | 2397192..2397929 | + | 738 | WP_002002796.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| BALH_RS12445 | 2398042..2398167 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| BALH_RS12455 | 2398441..2398722 | - | 282 | WP_001041559.1 | hypothetical protein | - |
| BALH_RS12460 | 2399002..2399238 | - | 237 | WP_001021690.1 | hypothetical protein | - |
| BALH_RS29720 | 2399577..2399753 | + | 177 | WP_000852618.1 | hypothetical protein | - |
| BALH_RS12470 | 2399897..2401366 | + | 1470 | WP_000287551.1 | beta-Ala-His dipeptidase | - |
| BALH_RS12475 | 2401952..2402422 | - | 471 | WP_000771846.1 | DUF5065 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28283.98 Da Isoelectric Point: 8.2998
>T21791 WP_002002796.1 NC_008600:2397192-2397929 [Bacillus thuringiensis str. Al Hakam]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNAAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTTFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNAAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTTFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T21791 NC_008600:2397192-2397929 [Bacillus thuringiensis str. Al Hakam]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGATTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAGATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATGCAGCAGTATTTGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGGGCGAAGATT
GTTGTATTTGAAGCAGCAAAGGAATTAAATACAACCTTTCGCGGTATCCGCTCGCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTTATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGATTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAGATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATGCAGCAGTATTTGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGGGCGAAGATT
GTTGTATTTGAAGCAGCAAAGGAATTAAATACAACCTTTCGCGGTATCCGCTCGCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTTATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT21791 WP_000588712.1 NC_008600:2398042-2398167 [Bacillus thuringiensis str. Al Hakam]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT21791 NC_008600:2398042-2398167 [Bacillus thuringiensis str. Al Hakam]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
GTTACAGCAAGTAGAAGAGTTAGAAGAAGAGTTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
GTTACAGCAAGTAGAAGAGTTAGAAGAAGAGTTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D3YFM0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366GQT1 |