Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200776..201536 Replicon chromosome
Accession NZ_CP084001
Organism Salmonella sp. A7

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LCS67_RS00930 Protein ID WP_000533909.1
Coordinates 201051..201536 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag LCS67_RS00925 Protein ID WP_000965889.1
Coordinates 200776..201063 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCS67_RS00910 (196274) 196274..198343 + 2070 WP_001291743.1 glycine--tRNA ligase subunit beta -
LCS67_RS00915 (198732) 198732..199160 + 429 Protein_182 IS3 family transposase -
LCS67_RS00920 (199525) 199525..200430 + 906 WP_000952518.1 hypothetical protein -
LCS67_RS00925 (200776) 200776..201063 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
LCS67_RS00930 (201051) 201051..201536 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LCS67_RS00935 (201908) 201908..202447 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
LCS67_RS00940 (202619) 202619..202831 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LCS67_RS00945 (203119) 203119..203409 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LCS67_RS00950 (203848) 203848..204558 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LCS67_RS00955 (204608) 204608..205582 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LCS67_RS00960 (205812) 205812..206474 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T217909 WP_000533909.1 NZ_CP084001:201051-201536 [Salmonella sp. A7]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T217909 NZ_CP114894:c1275693-1275590 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT217909 WP_000965889.1 NZ_CP084001:200776-201063 [Salmonella sp. A7]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT217909 NZ_CP114894:1275552-1275823 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References