Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4034655..4035250 Replicon chromosome
Accession NZ_CP083990
Organism Escherichia coli strain EC2648-Vir2

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag LCH23_RS19680 Protein ID WP_000239577.1
Coordinates 4034655..4035005 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LCH23_RS19685 Protein ID WP_001223208.1
Coordinates 4034999..4035250 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH23_RS19660 (4030101) 4030101..4031123 - 1023 WP_001313531.1 ABC transporter permease -
LCH23_RS19665 (4031137) 4031137..4032639 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
LCH23_RS19670 (4032779) 4032779..4033735 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LCH23_RS19675 (4034045) 4034045..4034575 + 531 WP_000055075.1 inorganic diphosphatase -
LCH23_RS19680 (4034655) 4034655..4035005 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
LCH23_RS19685 (4034999) 4034999..4035250 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LCH23_RS19690 (4035462) 4035462..4035803 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LCH23_RS19695 (4035806) 4035806..4039585 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T217904 WP_000239577.1 NZ_CP083990:c4035005-4034655 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T217904 NZ_CP114894:c573699-573592 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT217904 WP_001223208.1 NZ_CP083990:c4035250-4034999 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT217904 NZ_CP114894:573746-573812 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9XNP6


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References