Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3949644..3950458 Replicon chromosome
Accession NZ_CP083990
Organism Escherichia coli strain EC2648-Vir2

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag LCH23_RS19245 Protein ID WP_001054376.1
Coordinates 3949644..3949901 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag LCH23_RS19250 Protein ID WP_001309181.1
Coordinates 3949913..3950458 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH23_RS19220 (3944932) 3944932..3946038 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
LCH23_RS19225 (3946103) 3946103..3947083 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
LCH23_RS19230 (3947193) 3947193..3947398 + 206 Protein_3779 HNH endonuclease -
LCH23_RS19235 (3947666) 3947666..3948906 - 1241 Protein_3780 helicase YjhR -
LCH23_RS19240 (3949022) 3949022..3949153 + 132 WP_001309182.1 hypothetical protein -
LCH23_RS19245 (3949644) 3949644..3949901 + 258 WP_001054376.1 YjhX family toxin Toxin
LCH23_RS19250 (3949913) 3949913..3950458 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
LCH23_RS19255 (3950514) 3950514..3951260 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
LCH23_RS19260 (3951429) 3951429..3951647 + 219 Protein_3785 hypothetical protein -
LCH23_RS19265 (3951685) 3951685..3951801 + 117 Protein_3786 VOC family protein -
LCH23_RS19270 (3952046) 3952046..3953167 + 1122 WP_000010829.1 M42 family metallopeptidase -
LCH23_RS19275 (3953164) 3953164..3953442 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
LCH23_RS19280 (3953454) 3953454..3954767 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 3938654..3958682 20028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T217903 WP_001054376.1 NZ_CP083990:3949644-3949901 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T217903 NZ_CP114894:c573164-573057 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT217903 WP_001309181.1 NZ_CP083990:3949913-3950458 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT217903 NZ_CP114894:573211-573277 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References