Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 478902..479464 Replicon plasmid pGD0221
Accession NZ_CP083975
Organism Rhodococcus rhodochrous strain GD02

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KUM34_RS27750 Protein ID WP_085470959.1
Coordinates 478902..479192 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KUM34_RS27755 Protein ID WP_085470958.1
Coordinates 479189..479464 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUM34_RS27730 (KUM34_027735) 474801..476031 - 1231 Protein_430 IS3 family transposase -
KUM34_RS27735 (KUM34_027740) 476160..476393 + 234 WP_179161884.1 hypothetical protein -
KUM34_RS27740 (KUM34_027745) 476483..477053 - 571 Protein_432 SDR family NAD(P)-dependent oxidoreductase -
KUM34_RS27750 (KUM34_027755) 478902..479192 - 291 WP_085470959.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUM34_RS27755 (KUM34_027760) 479189..479464 - 276 WP_085470958.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KUM34_RS27760 (KUM34_027765) 479937..480110 + 174 WP_230825810.1 hypothetical protein -
KUM34_RS27765 480148..480282 + 135 WP_256062113.1 hypothetical protein -
KUM34_RS27770 (KUM34_027770) 480732..481256 + 525 WP_229583149.1 hypothetical protein -
KUM34_RS27775 (KUM34_027775) 481253..481873 + 621 WP_229583151.1 RES family NAD+ phosphorylase -
KUM34_RS27780 (KUM34_027780) 482021..482257 + 237 Protein_440 NADP-dependent isocitrate dehydrogenase -
KUM34_RS27785 (KUM34_027785) 482895..484352 - 1458 WP_265572788.1 replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..721409 721409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10818.32 Da        Isoelectric Point: 10.1476

>T217874 WP_085470959.1 NZ_CP083975:c479192-478902 [Rhodococcus rhodochrous]
VSDNPAARPGPYHVEVASPARRDLGRLPPRIVHAVIEFISGPLADNPHRLSKPLRDDLEGLHSARRGDYRILLRIDDPNH
TIVIVKIDHRAHAYRT

Download         Length: 291 bp

>T217874 NZ_CP114892:c4042039-4041761 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9749.91 Da        Isoelectric Point: 4.4936

>AT217874 WP_085470958.1 NZ_CP083975:c479464-479189 [Rhodococcus rhodochrous]
MTTVPLGEAKDKLSALVDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRADTRDAVAAADAEYAAGQTISLE
ELRAEHGMPSK

Download         Length: 276 bp

>AT217874 NZ_CP114892:c4042302-4042042 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References