Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 43321..44123 | Replicon | plasmid pB1-1-8 |
| Accession | NZ_CP083957 | ||
| Organism | Mesorhizobium sp. B1-1-8 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | - |
| Locus tag | FJ974_RS27885 | Protein ID | WP_140533553.1 |
| Coordinates | 43596..44123 (+) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | - |
| Locus tag | FJ974_RS27880 | Protein ID | WP_140533552.1 |
| Coordinates | 43321..43599 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FJ974_RS27865 (FJ974_27865) | 39451..40419 | + | 969 | WP_140533549.1 | plasmid partitioning protein RepB | - |
| FJ974_RS27870 (FJ974_27870) | 40575..41912 | + | 1338 | WP_226891696.1 | plasmid replication protein RepC | - |
| FJ974_RS27875 (FJ974_27875) | 42115..43221 | - | 1107 | WP_140533551.1 | site-specific integrase | - |
| FJ974_RS27880 (FJ974_27880) | 43321..43599 | + | 279 | WP_140533552.1 | DUF1778 domain-containing protein | Antitoxin |
| FJ974_RS27885 (FJ974_27885) | 43596..44123 | + | 528 | WP_140533553.1 | GNAT family N-acetyltransferase | Toxin |
| FJ974_RS27890 (FJ974_27890) | 44370..45323 | + | 954 | WP_140533554.1 | DUF1403 family protein | - |
| FJ974_RS27895 (FJ974_27895) | 45326..46024 | + | 699 | WP_140533555.1 | SMC-Scp complex subunit ScpB | - |
| FJ974_RS27900 (FJ974_27900) | 46059..46592 | - | 534 | WP_140533556.1 | RES family NAD+ phosphorylase | - |
| FJ974_RS27905 (FJ974_27905) | 46589..46975 | - | 387 | WP_140533557.1 | DUF2384 domain-containing protein | - |
| FJ974_RS27910 (FJ974_27910) | 47066..47377 | - | 312 | WP_226891697.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..494404 | 494404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 18940.79 Da Isoelectric Point: 7.1052
>T217870 WP_140533553.1 NZ_CP083957:43596-44123 [Mesorhizobium sp. B1-1-8]
VSLPPWHEEAIARSHDRKAFDCGDVEMNAFLQRFARQGHEQNAVKTFCAVPDDAPDKILGFYSLAPASVEHHAVPAAMTK
GLARHDVPEFLLARLAVDKSVAGKGLGGQLLLAAALRCIRVTEEVGGVLMIIDAKSKRAANWYASYGAEPLNDRPMTLVV
PLKTFAETLQASGHL
VSLPPWHEEAIARSHDRKAFDCGDVEMNAFLQRFARQGHEQNAVKTFCAVPDDAPDKILGFYSLAPASVEHHAVPAAMTK
GLARHDVPEFLLARLAVDKSVAGKGLGGQLLLAAALRCIRVTEEVGGVLMIIDAKSKRAANWYASYGAEPLNDRPMTLVV
PLKTFAETLQASGHL
Download Length: 528 bp
>T217870 NZ_CP114892:c2930076-2929969 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10130.71 Da Isoelectric Point: 10.5767
>AT217870 WP_140533552.1 NZ_CP083957:43321-43599 [Mesorhizobium sp. B1-1-8]
MARAALDDTDRMNIRVKPEVKARLLRAAALRHTDLTSFVTQSALREAETVIAEADAIKVSERDFGRILELLDNPPKPNAR
LRAAAAALPKNL
MARAALDDTDRMNIRVKPEVKARLLRAAALRHTDLTSFVTQSALREAETVIAEADAIKVSERDFGRILELLDNPPKPNAR
LRAAAAALPKNL
Download Length: 279 bp
>AT217870 NZ_CP114892:2930124-2930190 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|