Detailed information of TA system TA217869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4637052..4637650
• Replicon: chromosome
• Accession: NZ_CP083956
• Organism: Mesorhizobium sp. B1-1-8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FJ974_RS22900
• Protein ID: WP_140534137.1
• Coordinates: 4637357..4637650 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FJ974_RS22895
• Protein ID: WP_140534136.1
• Coordinates: 4637052..4637360 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJ974_RS22880 (FJ974_22880)	4633963..4634889	+	927	WP_140534134.1	peptidylprolyl isomerase	-
FJ974_RS22885 (FJ974_22885)	4635079..4636107	+	1029	WP_140534242.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
FJ974_RS22890 (FJ974_22890)	4636127..4636960	+	834	WP_140534243.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
FJ974_RS22895 (FJ974_22895)	4637052..4637360	+	309	WP_140534136.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FJ974_RS22900 (FJ974_22900)	4637357..4637650	+	294	WP_140534137.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FJ974_RS22905 (FJ974_22905)	4637688..4638362	-	675	WP_226891355.1	guanylate kinase	-
FJ974_RS22910 (FJ974_22910)	4638368..4639258	-	891	WP_140534139.1	YicC/YloC family endoribonuclease	-
FJ974_RS22915 (FJ974_22915)	4639406..4640668	-	1263	WP_140534141.1	endolytic transglycosylase MltG	-
FJ974_RS22920 (FJ974_22920)	4640831..4642093	-	1263	WP_140534143.1	beta-ketoacyl-ACP synthase II	-
FJ974_RS22925 (FJ974_22925)	4642128..4642364	-	237	WP_006203723.1	acyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-65)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10667.15 Da
• Isoelectric Point: 6.4630

>T217869 WP_140534137.1 NZ_CP083956:4637357-4637650 [Mesorhizobium sp. B1-1-8]
MKIVWSALALSDRDAIFTHIEADNPTAAIVIDERIVAATSRLRNFPESGRPGRLAGTRELVIVGTSYVAAYQLNEDTVRI
LRVLHGAQRWPDDLPAG

Nucleotide

• Length: 294 bp

>T217869 NZ_CP114892:2507325-2507789 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11291.86 Da
• Isoelectric Point: 5.1734

>AT217869 WP_140534136.1 NZ_CP083956:4637052-4637360 [Mesorhizobium sp. B1-1-8]
MPANALIQTRIDADIRDRASAVLENMGLTVSDAVRILLTRTANEGALPIDLLTNSEAYDVWFRAKVREALDDIRPDIPDD
LVEAHFAVRRAAARRKAGEPKP

Nucleotide

• Length: 309 bp

>AT217869 NZ_CP114892:2506990-2507325 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA