Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 4064588..4065158 | Replicon | chromosome |
| Accession | NZ_CP083956 | ||
| Organism | Mesorhizobium sp. B1-1-8 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | - |
| Locus tag | FJ974_RS19795 | Protein ID | WP_140537847.1 |
| Coordinates | 4064901..4065158 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | - |
| Locus tag | FJ974_RS19790 | Protein ID | WP_140537848.1 |
| Coordinates | 4064588..4064914 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FJ974_RS19755 (FJ974_19755) | 4059705..4060580 | + | 876 | WP_140537857.1 | zinc ABC transporter permease AztB | - |
| FJ974_RS19760 (FJ974_19760) | 4060603..4061544 | + | 942 | WP_140537855.1 | zinc ABC transporter substrate-binding protein AztC | - |
| FJ974_RS19765 (FJ974_19765) | 4061692..4062030 | + | 339 | WP_140537854.1 | TIGR01244 family sulfur transferase | - |
| FJ974_RS19770 (FJ974_19770) | 4062185..4062652 | - | 468 | WP_140537852.1 | Lrp/AsnC family transcriptional regulator | - |
| FJ974_RS19775 (FJ974_19775) | 4062791..4063906 | + | 1116 | WP_140537851.1 | 4-hydroxyphenylpyruvate dioxygenase | - |
| FJ974_RS19780 (FJ974_19780) | 4063970..4064197 | + | 228 | WP_140537850.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| FJ974_RS19785 (FJ974_19785) | 4064194..4064550 | + | 357 | WP_226891303.1 | type II toxin-antitoxin system VapC family toxin | - |
| FJ974_RS19790 (FJ974_19790) | 4064588..4064914 | - | 327 | WP_140537848.1 | BrnA antitoxin family protein | Antitoxin |
| FJ974_RS19795 (FJ974_19795) | 4064901..4065158 | - | 258 | WP_140537847.1 | BrnT family toxin | Toxin |
| FJ974_RS19800 (FJ974_19800) | 4065231..4065767 | - | 537 | WP_140537845.1 | DinB family protein | - |
| FJ974_RS19805 (FJ974_19805) | 4065793..4066806 | - | 1014 | WP_140537844.1 | fumarylacetoacetate hydrolase family protein | - |
| FJ974_RS19810 (FJ974_19810) | 4066803..4067708 | - | 906 | WP_181177268.1 | MBL fold metallo-hydrolase | - |
| FJ974_RS19815 (FJ974_19815) | 4067699..4069012 | - | 1314 | WP_140537840.1 | homogentisate 1,2-dioxygenase | - |
| FJ974_RS19820 (FJ974_19820) | 4069099..4069548 | + | 450 | WP_140537839.1 | MarR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9328.85 Da Isoelectric Point: 10.5888
>T217867 WP_140537847.1 NZ_CP083956:c4065158-4064901 [Mesorhizobium sp. B1-1-8]
MKIVWDEPKRLANIDKHGLDFAALDEEFFLASTIRAAKAGRFMAIGRVAGGVVAVVFARLGSEGFSMISMRPANQAERRL
FDGKT
MKIVWDEPKRLANIDKHGLDFAALDEEFFLASTIRAAKAGRFMAIGRVAGGVVAVVFARLGSEGFSMISMRPANQAERRL
FDGKT
Download Length: 258 bp
>T217867 NZ_CP114892:c2398532-2398236 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12309.82 Da Isoelectric Point: 10.3012
>AT217867 WP_140537848.1 NZ_CP083956:c4064914-4064588 [Mesorhizobium sp. B1-1-8]
MAKPKLNVTTPDKEFQPGRGFTKEDWDAVSDNPEWTEEDFRNARPFTEVFPDLAESIRRSRGRPALDNPKKQVTLRLDSD
VVARFRAGGPGWQSRINDILRKAAGLQK
MAKPKLNVTTPDKEFQPGRGFTKEDWDAVSDNPEWTEEDFRNARPFTEVFPDLAESIRRSRGRPALDNPKKQVTLRLDSD
VVARFRAGGPGWQSRINDILRKAAGLQK
Download Length: 327 bp
>AT217867 NZ_CP114892:c2398234-2397839 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|